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Type:	Artigo de Periódico
Title:	Lipid accumulation product index in HIV-infected patients: a marker of cardiovascular risk
Authors:	Milena Maria Moreira Guimarães Dirceu Bartolomeu Greco Allyson Nogueira Moreira Nathalia Sernizon Guimarães Cláudia Maria Vilas Freire Bruna Guimarães Rohlfs Lucas José de Campos Machado
Abstract:	The lipid accumulation product (LAP) index is an emerging cardiovascular risk marker. We aimed to assess the accuracy of this index as a marker of cardiovascular risk in HIV-infected patients. A cross-sectional study of 133 HIV-infected patients on antiretroviral drugs and 20 non-infected controls was conducted atthe outpatient clinic of a referral center of infectious and parasitic diseases. Evaluations included LAP index, homeostasis model assessment (HOMA) index, anthropometric measurements, blood pressure, glucose tolerance test, and cholesterol and triglyceride levels. Body mass index (BMI) was similar in both groups; how ever, waist circumference was greater in the HIV-infected patients. Triglyceride levels were significantly higher (p < 0.001) and HDL cholesterol levels were lower in HIV-infected patients (p < 0.001). Plasma glucose (p = 0.01) and insulin (p = 0.005) levels two hours after a glucose load, HOMA-IR index (p < 0.001) and LAP index (p < 0.001) were higher in the HIV-infected patients. A positive and significant correlation was found between HOMA-IR index and LAP (r = 0.615; p < 0.01), BMI (r = 0.334; p < 0.01) and waist circumference (r = 0.452; p < 0.01) in the HIV-infected patients. In male HIV-infected patients and controls, ROC curve analyses revealed that the best cut-off value of LAP to define the presence of insulin resistance was 64.8 (sensitivity 86%, specificity 77% and area under the curve 0.824). These results confirm that insulin resistance is more common in HIV-patients on antiretroviral drugs than in HIV negative controls. A positive and significant correlation was found between the LAP index and the HOMA index, with LAP ≥ 64.8 constituting an additional risk factor for cardiovascular disease in male HIV patients.
Subject:	Hiperlipidemia Aterosclerose Fatores de Risco de Doenças Cardíacas Resistência à Insulina HIV
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	FAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA MED - DEPARTAMENTO DE CLÍNICA MÉDICA
Rights:	Acesso Aberto
metadata.dc.identifier.doi:	10.1016/j.bjid.2018.03.006
URI:	http://hdl.handle.net/1843/56916
Issue Date:	22-Apr-2018
metadata.dc.url.externa:	https://www.sciencedirect.com/science/article/pii/S1413867018300199?via%3Dihub
metadata.dc.relation.ispartof:	The Brazilian Journal of Infectious Diseases
Appears in Collections:	Artigo de Periódico

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