Síntese, caracterização e avaliação do perfil de liberação "in vitro" de hidrogéis do álcool polivinílico ph sensitivos processados por métodos físico-químico

Abstract

In this study hydrogels of poly(vinyl alcohol) (PVA) processed by chemical method and gamma radiation were obtained in order to evaluate the pH responsive behaviour of those systems as well the utilization for the targeted drug delivery in the gastrointestinal tract of Human. The rheological properties of PVA solutions with different hydrolysis degree and weight mass were evaluated as well your chemical structure through infrared and ultraviolet spectroscopy. The crosslinking was made with glutaraldehyde and citric acid/gamma radiation. The hydrogels were analyzed on the effectiveness ofthe crosslink bounds by the presence of characteristics chemicals groups in the infrared spectra, after crosslinking. In addition based on the infrared spectrum obtained the degree of cristallinity was studied. The pH-responsive behavior and the potential utilization on the targeted drug delivery were measured by the swelling and in vitro test, in different pHs. The active ingredient, mesalazine, was loaded during the crosslinkingprocess of PVA and glutaraldehyde. The results showed that the increase of viscosity is related with the hydrolysis degree and the weight mass of the polymer. Furthermore the swelling tests demonstrated that the PVA hydrogels processed showed different behaviors when submitted in different pHs, meaning that pH 6 was higher than pH 3. The in vitro release profile showed, in tested pHs, a burst effect in the first two hoursand a slower release afterwards. In the PVA hydrogel crosslinked with GA, the higher release of mesalazine was obtained in pH 6 and the lowest in pH 3. As expected the release of mesalazine loaded into the PVA not crosslinked was superior when compared with the results obtained in the PVA hydrogels crosslinked with GA. This suggests that the proposal hydrogel could be used as a potential drug target deliverysystem.