Exploiting 4-1BB costimulation for enhancing antiviral vaccination
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Harrison, Jodie; Bertram, Edward; Ramshaw, Ian
Description
4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily, is emerging as an important costimulatory molecule, particularly in the regulation of CD8+ T cell responses. Costimulation through 4-1BB, such as by utilizing agonistic anti-4-1BB monoclonal antibodies, has been well studied in various tumor models. However, 4-1BB is also an important regulator of antiviral CD8+ T cell responses. This review summarizes these findings and describes how 4-1BB is beginning to be exploited in...[Show more]
Collections | ANU Research Publications |
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Date published: | 2006 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/19315 |
Source: | Viral Immunology |
DOI: | 10.1089/vim.2006.0054 |
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