Effect of stilbenoid polyphenols on resistance artery structure and mechanical properties in the spontaneously hypertensive heart failure rat
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Date
2017-28-02
Authors
Lee, Danielle
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Abstract
Small resistance arteries affect total peripheral resistance (TPR). Increased blood pressure (BP) in hypertension is proportionate to changes in cardiac output (CO) and TPR. Thus, it is imperative to examine compounds that affect microvascular parameters. Resveratrol (trans-3,5,4’-trihydroxystilbene), a stilbenoid polyphenol, has gained significant research interest and is purportedly linked to improved longevity and cardiovascular health. Although resveratrol is well-tolerated in humans, it is readily metabolized and exhibits low bioavailability and half-life. I hypothesized that resveratrol analogues with altered pharmacokinetics and pharmacodynamics would produce greater vasculoprotective effects in an experimental model of hypertension and heart failure.
Description
Keywords
Resveratrol, Polyphenols, Resistance arteries, Stilbenes, Pterostilbene, Gnetol, Hypertension
Citation
Lee, D. I., Acosta, C., Anderson, C. M., & Anderson, H. D. (2017). Peripheral and Cerebral Resistance Arteries in the Spontaneously Hypertensive Heart Failure Rat: Effects of Stilbenoid Polyphenols. Molecules, 22(3). doi:10.3390/molecules22030380