Ver ítem
- xmlui.general.dspace_homeCentros e Institutos de InvestigaciónCICVyA. Centro de Investigación en Ciencias Veterinarias y AgronómicasInstituto de BiotecnologíaArtículos científicosxmlui.ArtifactBrowser.ItemViewer.trail
- Inicio
- Centros e Institutos de Investigación
- CICVyA. Centro de Investigación en Ciencias Veterinarias y Agronómicas
- Instituto de Biotecnología
- Artículos científicos
- Ver ítem
Protection efficacy of Argentinian isolates of Mycobacterium avium subsp. paratuberculosis with different genotypes and virulence in a murine model
Resumen
Paratuberculosis is a chronic disease caused by Mycobacterium avium subsp. paratuberculosis (Map). The disease causes economic losses and, therefore, it is imperative to follow proper control strategies, which should include an effective vaccine. Several strategies have assessed the virulence and immune response of Map strains that could be used as a vaccine. This study evaluates the degree of virulence, immune response, and protection of Argentinian
[ver mas...]
Paratuberculosis is a chronic disease caused by Mycobacterium avium subsp. paratuberculosis (Map). The disease causes economic losses and, therefore, it is imperative to follow proper control strategies, which should include an effective vaccine. Several strategies have assessed the virulence and immune response of Map strains that could be used as a vaccine. This study evaluates the degree of virulence, immune response, and protection of Argentinian strains of Map with different genotype in a murine model. Four local isolates (Cattle type) with different genotypes (analyzed by MIRU-VNTR and SSRs) were selected and evaluated in a virulence assay in BALB/c mice. This assay allowed us to differentiate virulent and low-virulence Map strains. The less virulent strains (1543/481 and A162) failed to induce a significant production of the proinflammatory cytokine IFNg, whereas the virulent strain 6611 established infection along with a proinflammatory immune response. On the other hand, the virulent strain 1347/498 was efficient in establishing a persistent infection, but failed to promote an important Th1 response compared with 6611 at the evaluated time. We selected the low-virulence strain 1543/498 as a live vaccine and the virulent strain 6611 as a live and inactivated vaccine in a protection assay in mice. Strain 1543/481 failed to protect the animals from challenge, whereas strain 6611, in its live and inactivated form, significantly reduced the CFUs count in the infected mice, although they had different immunological response profiles. The inactivated virulent strain 6611 is a potential vaccine candidate against paratuberculosis to be tested in cattle.
[Cerrar]

Autor
Colombatti Olivieri, Maria Alejandra;
Moyano, Roberto Damian;
Traveria, Gabriel Eduardo;
Alvarado Pinedo, Maria Fiorella;
Mon, Maria Laura;
Gravisaco, María José;
Delgado, Fernando Oscar;
Santangelo, María De La Paz;
Romano, Maria Isabel;
Fuente
Research in veterinary science 121 : 4-11. (December 2018)
Fecha
2018-12
Editorial
Elsevier
ISSN
0034-5288
Formato
pdf
Tipo de documento
artículo
Palabras Claves
Derechos de acceso
Restringido

Metadatos
Mostrar el registro completo del ítemÍtems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Evaluation of a virulent strain of Mycobacterium avium subsp. Paratuberculosis used as a heat-killed vaccine
Colombatti Olivieri, Maria Alejandra; Moyano, Roberto Damian; Mon, Maria Laura; Gravisaco, María José; Alvarado Pinedo, María Fiorella; Delgado, Fernando Oscar; Hernández Pando, Rogelio; Alonso, Maria Natalia; Cuerda, Maria Ximena; Santangelo, María De La Paz; Romano, Maria Isabel (Elsevier, 2021-11)Bovine paratuberculosis is one of the most important chronic infectious diseases in livestock. This disease is difficult to control because of its inefficient management (test and cull strategy and inadequate biosecurity). ... -
Mapa Nacional de Cultivos campaña 2023/2024. Versión 1. Publicación N°6
De Abelleyra, Diego; Iturralde Elortegui, Maria Del Rosario Ma; Zelaya, Daniela Karina; Portillo, Javier Esteban; Melilli, Maria Paula; Franzoni, Agustin; Volante, Jose Norberto; Goytia, Silvia Yanina; Kurtz, Ditmar Bernardo; Ybarra, Diego Daniel; Barrios, Raúl Ariel; Benedetti, Pablo Eduardo; Morales, Cristina Del Carmen; Berriolo, Maria Jimena; Lanceta Pereyra, Martín Miguel; Scavone, Andrea Soledad; Murray, Francisco; Santillan, Jorge Luis; Continelli, Noelia; Gerlero, Gustavo Daniel; Salas, Diego Gabriel; Reinaldi, Javier Aníbal; Lopez Juane, Pablo Alejandro; Gomez, Dino Gerardo; Krapovickas, Sebastian; Sapino, Veronica; Regonat, Arturo Jose; Cracogna, Mariano Federico; Espindola, Carlos María; Valiente, Sebastián Omar; Parodi, Maria Ines; Colombo, Facundo; Scarel, Julieta Haydee; Ayala, Jorge Omar Antonio; Martins, Luciano; Basanta, Maria; Rausch, Analia Fabiana; Almada, Gustavo; Boero, Leandro Ruben; Calcha, Jose Alfredo Nicolas; Chiavassa, Alejandro Ariel; Calandroni, Mirta; Murillo, Natalia Lorena; Pascal, Beatriz Liliana; Borrachi, Sebastian Emilio; Erreguerena, Juan María; Besteiro, Ignacio; Oyesqui, Lia Ana; Lezaeta, Maria Emilia; Pezzola, Nestor Alejandro; Winschel, Cristina Ines; Rodriguez Perez, Jonathn Jose; German, Leonardo Ariel; Vitale, Juan Pablo (Programa Nacional de Recursos Naturales y Gestión Ambiental, INTA, 2024-10)Mapa de tipos de cultivos que cubre las principales áreas agrícolas de Argentina para la temporada de crecimiento 2023/2024. Esta versión incluye dos mapas diferentes para cultivos de invierno y verano. Los mapas se generaron ... -
Buenas prácticas lecheras : guía para la implementación en la producción de leche bovina
Aimar, María Verónica; Amalfi, José María; Campos Carlés, Silvina; Charlon, Veronica; Cristiano, Gabriela; Delbino, Fernando; Diaz Cano, Muncha; Estevez Acuña, Rodrigo Rubén; Gigli, Isabel; Glauber, Claudio Eduardo; Guillermón, José; Ibargoyen, José María; Iorio, Jesica Daniela; Jaureguiberry, Horacio Sebastián; Jarkowsky, Andrés; Lesman, María de los Ángeles; Llano, Agustina; Mazzitelli, José; Moro, Santiago; Mozeris, Gustavo; Negri Rodriguez, Livia Maria; Olivieri, Daniela Ivana; Osan, Oscar; Pérez, Gabriela Guadalupe; Preumayr, Fernando Martín; Serrano, Pedro Miguel; Tonero, María Eugenia; Trombert, José María; Troya, Paula; Urruspuru, María Luz; Varaldo, Estefanía (Red de Buenas Prácticas Agropecuarias - BPA, 2021-03)Las “Buenas Prácticas Agropecuarias” hacen referencia a una producción sana, segura y amigable con el ambiente, los animales y las personas. Son numerosos los temas que abarca e involucra la producción primaria de leche: ...