Bioresorbable stent in anterior cruciate ligament reconstruction
Authors:
- Krzysztof Ficek,
- Jolanta Rajca,
- Mateusz Stolarz,
- Ewa Stodolak-Zych,
- Jarosław Wieczorek,
- Małgorzata Muzalewska,
- Marek Wyleżoł,
- Zygmunt Wróbel,
- Marcin Binkowski,
- Stanisław Błażewicz
Abstract
The exact causes of failure of anterior cruciate ligament (ACL) reconstruction are still unknown. A key to successful ACL reconstruction is the prevention of bone tunnel enlargement (BTE). In this study, a new strategy to improve the outcome of ACL reconstruction was analyzed using a bioresorbable polylactide (PLA) stent as a catalyst for the healing process. The study included 24 sheep with 12 months of age. The animals were randomized to the PLA group (n = 16) and control group (n = 8), subjected to the ACL reconstruction with and without the implantation of the PLA tube, respectively. The sheep were sacrificed 6 or 12 weeks post-procedure, and their knee joints were evaluated by X-ray microcomputed tomography with a 50 μm resolution. While the analysis of tibial and femoral tunnel diameters and volumes demonstrated the presence of BTE in both groups, the enlargement was less evident in the PLA group. Also, the microstructural parameters of the bone adjacent to the tunnels tended to be better in the PLA group. This suggested that the implantation of a bioresorbable PLA tube might facilitate osteointegration of the tendon graft after the ACL reconstruction. The beneficial effects of the stent were likely associated with osteogenic and osteoconductive properties of polylactide.
- Record ID
- USL4351627e17f94803a097f3b7c8a6a8d5
- Author
- Journal series
- Polymers, ISSN 2073-4360
- Issue year
- 2019
- Vol
- 11
- No
- 12
- Pages
- 1-20
- Publication size in sheets
- 1.00
- Keywords in English
- anterior cruciate ligament reconstruction, bone tunnel enlargement, X-raymicrotomography, polylactide
- ASJC Classification
- ;
- DOI
- DOI:10.3390/polym11121961 Opening in a new tab
- Handle.net URL
- hdl.handle.net/20.500.12128/12700 Opening in a new tab
- Language
- eng (en) English
- License
- File
-
- File: 1
- Bioresorbable stent in anterior cruciate ligament reconstruction, File Ficek_Bioresorbable_stent_in_anterior_cruciate.pdf / 2 MB
- Ficek_Bioresorbable_stent_in_anterior_cruciate.pdf
- publication date: 06-02-2024
- Bioresorbable stent in anterior cruciate ligament reconstruction, File Ficek_Bioresorbable_stent_in_anterior_cruciate.pdf / 2 MB
-
- Score (nominal)
- 100
- Score source
- journalList
- Score
- = 100.0, 11-04-2024, ArticleFromJournal
- Publication indicators
- Citation count
- 14
- Uniform Resource Identifier
- https://opus.us.edu.pl/info/article/USL4351627e17f94803a097f3b7c8a6a8d5/
- URN
urn:uni-kat-prod:USL4351627e17f94803a097f3b7c8a6a8d5
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.