The effect of vitamin D, magnesium and zinc supplements on interferon signaling pathways and their relationship to control SARS-CoV-2 infection
Authors:
- Mohsen Nabi-Afjadi,
- Hadis Karami,
- Kaveh Goudarzi,
- Iraj Alipourfard,
- Elham Bahreini
Abstract
The concern of today's communities is to find a way to prevent or treat COVID-19 and reduce its symptoms in the patients. However, the genetic mutations and more resistant strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerge; the designed vaccines and adjuvant therapies would potentially control the symptoms and severity of COVID-19. The most important complication of this viral infection is acute respiratory distress syndrome, which occurs due to the infiltration of leukocytes into the alveoli and the raised cytokine storm. Interferons, as a cytokine family in the host, play an important role in the immune-related antiviral defense and have been considered in the treatment protocols of COVID-19. In addition, it has been indicated that some nutrients, including vitamin D, magnesium and zinc are essential in the modulation of the immune system and interferon (IFN) signaling pathway. Several recent studies have investigated the treatment effect of vitamin D on COVID-19 and reported the association between optimal levels of this vitamin and reduced disease risk. In the present study, the synergistic action of vitamin D, magnesium and zinc in IFN signaling is discussed as a treatment option for COVID-19 involvement.
- Record ID
- USL01c6d5488b8a4a318415ac04c61e4e85
- Author
- Journal series
- Clinical and Molecular Allergy, ISSN 1476-7961
- Issue year
- 2021
- Vol
- 19
- No
- 21
- Pages
- 1-10
- Publication size in sheets
- 0.50
- Article number
- 21
- Keywords in English
- COVID-19, Interferon, Vitamin D, Magnesium, Zinc
- ASJC Classification
- ; ;
- DOI
- DOI:10.1186/s12948-021-00161-w Opening in a new tab
- Handle.net URL
- hdl.handle.net/20.500.12128/21895 Opening in a new tab
- URL
- http://hdl.handle.net/20.500.12128/21895 Opening in a new tab
- Language
- eng (en) English
- License
- File
-
- File: 1
- The effect of vitamin D, magnesium and zinc supplements on interferon signaling pathways and their relationship to control SARS-CoV-2 infection, File Alipourfard_the_effect_of_vitamin_d.pdf / 1 MB
- Alipourfard_the_effect_of_vitamin_d.pdf
- publication date: 06-02-2024
- The effect of vitamin D, magnesium and zinc supplements on interferon signaling pathways and their relationship to control SARS-CoV-2 infection, File Alipourfard_the_effect_of_vitamin_d.pdf / 1 MB
-
- Score (nominal)
- 100
- Score source
- journalList
- Score
- = 100.0, 15-09-2023, ArticleFromJournal
- Publication indicators
- Citation count
- 25
- Uniform Resource Identifier
- https://opus.us.edu.pl/info/article/USL01c6d5488b8a4a318415ac04c61e4e85/
- URN
urn:uni-kat-prod:USL01c6d5488b8a4a318415ac04c61e4e85
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.