Interstitial pneumonia with autoimmune ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Interstitial pneumonia with autoimmune features: Evaluation of connective tissue disease incidence during follow-up.
Auteur(s) :
Decker, Paul [Auteur]
Centre régional de compétence des Maladies systémiques et auto-immunes rares de l'adulte et Maladies vasculaires rares
Centre Hospitalier Universitaire de Nancy [CHU Nancy]
Sobanski, Vincent [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE (Ex-Liric)]
Centre National de Référence des Maladies Auto-Immunes Systémiques Rares du Nord et Nord-Ouest de France [CeRAINO]
Moulinet, T. [Auteur]
Ingénierie Moléculaire et Physiopathologie Articulaire [IMoPA]
Service de Médecine Interne et Médecine Générale [CHRU Nancy]
Launay, David [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Hachulla, Eric [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Valentin, Victor [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Centre de référence des maladies auto-immunes systémiques rares du Nord et Nord Ouest [CHRU Lille]
Godbert, Benoit [Auteur]
Revuz, S. [Auteur]
Guillaumot, A. [Auteur]
Service de Pneumologie [CHRU Nancy]
Gomez, E. [Auteur]
Chabot, F. [Auteur]
Service de Pneumologie [CHRU Nancy]
Wémeau, Lidwine [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Jaussaud, R. [Auteur]
Centre régional de compétence des Maladies systémiques et auto-immunes rares de l'adulte et Maladies vasculaires rares
Centre Hospitalier Universitaire de Nancy [CHU Nancy]
Sobanski, Vincent [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE (Ex-Liric)]
Centre National de Référence des Maladies Auto-Immunes Systémiques Rares du Nord et Nord-Ouest de France [CeRAINO]
Moulinet, T. [Auteur]
Ingénierie Moléculaire et Physiopathologie Articulaire [IMoPA]
Service de Médecine Interne et Médecine Générale [CHRU Nancy]
Launay, David [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Hachulla, Eric [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Valentin, Victor [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Centre de référence des maladies auto-immunes systémiques rares du Nord et Nord Ouest [CHRU Lille]
Godbert, Benoit [Auteur]
Revuz, S. [Auteur]
Guillaumot, A. [Auteur]
Service de Pneumologie [CHRU Nancy]
Gomez, E. [Auteur]
Chabot, F. [Auteur]
Service de Pneumologie [CHRU Nancy]
Wémeau, Lidwine [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Jaussaud, R. [Auteur]
Titre de la revue :
European Journal of Internal Medicine
Nom court de la revue :
Eur J Intern Med
Date de publication :
2021-12-29
ISSN :
1879-0828
Mot(s)-clé(s) en anglais :
Interstitial pneumonia with autoimmune features
Interstitial lung disease
Connective tissue disease
Antisynthetase syndrome
Systemic sclerosis
Interstitial lung disease
Connective tissue disease
Antisynthetase syndrome
Systemic sclerosis
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Objectives
Among interstitial pneumonia with autoimmune features (IPAF) patients, identifying those at risk to develop a connective tissue disease (CTD) during the disease course is a key issue. The aim of this study was ...
Lire la suite >Objectives Among interstitial pneumonia with autoimmune features (IPAF) patients, identifying those at risk to develop a connective tissue disease (CTD) during the disease course is a key issue. The aim of this study was to evaluate the incidence of definite CTD diagnosis in IPAF patients during follow-up. Methods We performed a multicentric cohort study of interstitial lung disease (ILD) from 2010 to 2017 in pneumology and immunology departments of tertiary care centers. Patients with a known cause of ILD (including established CTD) at diagnosis were excluded. Among patients with idiopathic ILD and at least three years of follow-up, two groups (IPAF and non-IPAF) were retrospectively analyzed at time of diagnosis. Results A total of 249 patients with ILD were enrolled, including 70 IPAF and 179 non-IPAF patients. After a mean follow-up time of 77 ± 44 months, 18/70 IPAF patients (26%) had a CTD diagnosis – 9 antisynthetase syndrome, 8 systemic sclerosis and 1 overlap myositis – compared with 4/179 non-IPAF patients (2%). IPAF patients were at higher risk of CTD occurrence at 3 years of follow-up compared to non-IPAF patients (HR 10.1, 95% CI 3.1–33.1, p < 0. 01). IPAF patients progressing to CTD tended to be younger, more often female and have more frequently puffy fingers, capillaroscopy abnormalities and antisynthetase antibodies at diagnosis. Conclusions We found that a significant proportion of IPAF patients had associated CTD diagnosis during follow-up. Prospective studies are needed to confirm baseline predictive factors of CTD occurrence in IPAF patients.Lire moins >
Lire la suite >Objectives Among interstitial pneumonia with autoimmune features (IPAF) patients, identifying those at risk to develop a connective tissue disease (CTD) during the disease course is a key issue. The aim of this study was to evaluate the incidence of definite CTD diagnosis in IPAF patients during follow-up. Methods We performed a multicentric cohort study of interstitial lung disease (ILD) from 2010 to 2017 in pneumology and immunology departments of tertiary care centers. Patients with a known cause of ILD (including established CTD) at diagnosis were excluded. Among patients with idiopathic ILD and at least three years of follow-up, two groups (IPAF and non-IPAF) were retrospectively analyzed at time of diagnosis. Results A total of 249 patients with ILD were enrolled, including 70 IPAF and 179 non-IPAF patients. After a mean follow-up time of 77 ± 44 months, 18/70 IPAF patients (26%) had a CTD diagnosis – 9 antisynthetase syndrome, 8 systemic sclerosis and 1 overlap myositis – compared with 4/179 non-IPAF patients (2%). IPAF patients were at higher risk of CTD occurrence at 3 years of follow-up compared to non-IPAF patients (HR 10.1, 95% CI 3.1–33.1, p < 0. 01). IPAF patients progressing to CTD tended to be younger, more often female and have more frequently puffy fingers, capillaroscopy abnormalities and antisynthetase antibodies at diagnosis. Conclusions We found that a significant proportion of IPAF patients had associated CTD diagnosis during follow-up. Prospective studies are needed to confirm baseline predictive factors of CTD occurrence in IPAF patients.Lire moins >
Langue :
Anglais
Comité de lecture :
Oui
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Université de Lille
Inserm
CHU Lille
Inserm
CHU Lille
Date de dépôt :
2024-01-12T05:22:16Z
2024-03-01T09:06:29Z
2024-03-01T09:06:29Z