Titre :

Actn3 genotype influences masseter muscle characteristics and self-reported bruxism

Auteur(s) :

Nicot, Romain [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Raoul, Gwénaël [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Vieira, Alexandre R. [Auteur]
University of Pittsburgh School of Medicine
Ferri, Joel [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Sciote, James J. [Auteur]

Titre de la revue :

Oral Diseases

Nom court de la revue :

Oral Dis

Date de publication :

2021-11-13

ISSN :

1601-0825

Mot(s)-clé(s) :

masseter muscle
sleep bruxism
malocclusion
bruxism
human
ACTN3 protein
temporomandibular joint disorders

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

OBJECTIVE: Main aim of the study was to explore the association between genetic polymorphisms in ACTN3 and bruxism. Secondary objectives included masseter muscle phenotypes assessment between bruxers and non-bruxers and ...
Lire la suite >OBJECTIVE: Main aim of the study was to explore the association between genetic polymorphisms in ACTN3 and bruxism. Secondary objectives included masseter muscle phenotypes assessment between bruxers and non-bruxers and according to genetic polymorphisms in ACTN3. METHODS: Fifty-four patients undergoing orthognathic surgery for correction of their malocclusion were enrolled. Self-reported bruxism and temporomandibular disorders status were preoperatively recorded. Saliva samples were used for ACTN3 genotyping. Masseter muscle samples were collected bilaterally at the time of orthognathic surgery to explore the muscle fiber characteristics. RESULTS: There were significant differences in genotypes for rs1815739 (R577X nonsense) (p = 0.001), rs1671064 (Q523R missense) (p = 0.005), and rs678397 (intronic variant) (p = 0.001) between bruxers and non-bruxers. Patients with self-reported bruxism presented a larger mean fiber area for types IIA (p = 0.035). The mean fiber areas in individuals with the wild-type CC genotype for rs1815739 (R577X) were significantly larger for type IIA fibers (1394.33 μm222222 CONCLUSIONS: ACTN3 genotypes influence self-reported bruxism in patients with dentofacial deformity through specific masseter muscle fiber characteristics.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Advanced Drug Delivery Systems (ADDS) - U1008

Équipe(s) de recherche :

U1008

Date de dépôt :

2022-04-13T07:12:16Z
2024-01-22T14:19:25Z