In recent decades, the global consumption of fossil fuels has increased significantly, which has affected the amount of CO2 emissions. A large part of the total CO2 emissions is produced by the transport sector, so in this thesis we focus on advanced drive systems for vehicles with lower energy consumption and lower CO2 emissions compared to a conventional drive system with an internal combustion engine. We compare the drive system with an electric machine, the drive system with an internal combustion engine and the hybrid drive system. These drive systems are evaluated with a calculation program that was specifically developed in the Python programming language as part of the thesis. The computer program enables the calculation of energy consumption and CO2 emissions of the drive system during the driving cycle. Industry-accepted driving cycles such as Braunschweig, CSHVC and ETC are used to calculate the energy consumption and CO2 emissions of the drive system of heavy-duty vehicles. A graphical interface was created as part of the calculation program, which allows setting the properties of the simulated vehicle and displaying the results. As part of the thesis, the validation of the calculation program was carried out with the industry-accepted AVL Cruise M program. At the same time, in the course of the thesis, a comparative analysis was made with the aim of comparing drive systems for buses of intercity public passenger transport, where we found that the hybrid drive system and the drive system with an electric motor consume much less energy during operation compared to the drive system with internal combustion engine. Nevertheless, we find that the hybrid drive system produces significantly less CO2 emissions compared to the drive system with only internal combustion engine.