Identificador para citar o enlazar este ítem: http://hdl.handle.net/20.500.13003/9733
Chromium Exposure and Risk of Cardiovascular Disease in High Cardiovascular Risk Subjects - Nested Case-Control Study in the Prevention With Mediterranean Diet (PREDIMED) Study
Identificadores
ISSN: 1346-9843
eISSN: 1347-4820
WOS ID: 000408462800019
Scopus EID: 2-s2.0-85025804076
PMID: 28392547
Embase PUI: L617522129
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Gutierrez-Bedmar, Mario; Angel Martinez-Gonzalez, Miguel; Munoz-Bravo, Carlos; Ruiz-Canela, Miguel; Mariscal, Alberto; Salas-Salvado, Jordi; Estruch, Ramon; Corella, Dolores; Aros, Fernando; Fito, Montserrat; Lapetra, Jose; Serra-Majem, Lluis; Pinto, Xavier; Alonso-Gomez, Angel; Portoles, Olga; Fiol Sala, Miquel ; Bullo, Monica; Castaner, Olga; Ros, Emilio; Gomez-Gracia, EnriqueFecha de publicación
2017-08Tipo de documento
research articleCitación
Gutierrez-Bedmar Mario, Angel Martinez-Gonzalez Miguel, Muñoz-Bravo Carlos, Ruiz-Canela Miguel, Mariscal Alberto, Salas-Salvado Jordi, et al. Chromium Exposure and Risk of Cardiovascular Disease in High Cardiovascular Risk Subjects - Nested Case-Control Study in the Prevention With Mediterranean Diet (PREDIMED) Study. Circ J. 2017 Aug;81(8):1183-+. Epub 2017 Apr 8.Resumen
Background: Epidemiological data on chromium (Cr) exposure and the risk of cardiovascular disease (CVD) are still limited. Toenail Cr level (TCL) provides a time-integrated measure reflecting long-term Cr exposure. We measured TCL to assess the hypothesis that long-term Cr exposure was inversely associated with incident CVD in a population at high risk for CVD. Methods and Results: The associations between TCL and CVD were evaluated in a case-control study nested within the PREvencion con Dleta MEDiterranea (PREDIMED) trial. We randomly selected 147 of the 288 patients diagnosed with CVD during follow-up and matched them on age and sex to 271 controls. Instrumental neutron activation analysis was used to assess TCL. In-person interviews, medical record reviews, and validated questionnaires were used to assess covariates. The fully adjusted OR for the highest vs. lowest quartile of toenail Cr was 0.54 (95% CI: 0.26-1.14; P-trend=0.189) for the nested case-control study. On stratification for diabetes mellitus (DM), OR was 1.37 (95% CI: 0.54-3.46; P-trend=0.364) for the DM group, and 0.25 (95% CI: 0.08-0.80; P-trend=0.030) for the non-DM group (P for interaction=0.078). Conclusions: The present findings, although not statistically significant, are consistent with previously reported inverse associations between TCL and CVD. These results, especially for non-DM patients, increase the limited epidemiological knowledge about the possible protective role of Cr against CVD.
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https://dx.doi.org/10.1253/circj.CJ-17-0032Palabras clave
Cardiovascular diseaseChromium
Diabetes
PREDIMED
Toenail biomarker
MeSH
Cardiovascular DiseasesChromium
Aged, 80 and over
Aged
Male
Case-Control Studies
Spain
Female
Risk Factors
Diet, Mediterranean
Humans
Middle Aged
DeCS
Dieta MediterráneaFactores de Riesgo
Humanos
Persona de Mediana Edad
Anciano
Anciano de 80 o más Años
Femenino
Enfermedades Cardiovasculares
Cromo
España
Estudios de Casos y Controles
Masculino
Colecciones de Docusalut en las que aparece este ítem
Hospital Universitario Son Espases - HUSE > Comunicación científicaInstituto de Investigación Sanitaria Islas Baleares - IDISBA > Comunicación científica