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Nitric oxide-dependent endothelial function and cardiovascular disease.

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Desjardins, Fanny [UCL] Balligand, Jean-Luc [UCL]

Nitric oxide produced by three different isoforms of nitric oxide synthase (NOS) widely expressed in virtually all vascular cell types is mostly produced by the endothelial isoform (eNOS) in endothelial cells where it plays a crucial role in vascular tone and structure regulation. It also exerts an anti-inflammatory influence, inhibits platelets adhesion and aggregation, and prevents smooth muscle cells proliferation and migration. Several lines of evidence link endothelial dysfunction, characterized by decreased bioavailability of nitric oxide, with the development of many pathological conditions such as heart failure, hypertension, diabetes and atherosclerosis. This review focuses on nitric oxide-dependent endothelial dysfunction in cardiovascular diseases, its clinical detection and relevance, potential pathogenic mechanisms and possible therapies.

Document type Article de périodique (Journal article) – Journal Article, Review
Access type Accès restreint
Publication date 2006
Journal information "Acta clinica Belgica" - Vol. 61, no. 6, p. 326-34 (2006)
Peer reviewed yes
issn 0001-5512
Publication status Publié
Affiliations UCL - MD/MINT - Département de médecine interne
UCL - (SLuc) Service de médecine interne et maladies infectieuses (MIMI)
MESH Subject Cardiovascular Diseases - physiopathology ; Down-Regulation - physiology ; Endothelium, Vascular - physiopathology ; Humans ; Nitric Oxide - metabolism - physiology ; Nitric Oxide Synthase - physiology ; Nitric Oxide Synthase Type III - physiology ; PPAR gamma - metabolism ; Phosphorylation ; Signal Transduction - physiology
Links
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Bibliographic reference Desjardins, Fanny ; Balligand, Jean-Luc. Nitric oxide-dependent endothelial function and cardiovascular disease.. In: Acta clinica Belgica, Vol. 61, no. 6, p. 326-34 (2006)
Permanent URL http://hdl.handle.net/2078.1/10875