Real-time, label-free and selective impedimetric detection of bacteria using CMOS-compatible microelectrodes in a fluidic cell

Couniot, Numa [UCL] Vanzieleghem, Thomas [UCL] Rasson, Jonathan [UCL] Van Overstraeten, Nancy [UCL] Poncelet, Olivier [UCL] Mahillon, Jacques [UCL] Francis, Laurent [UCL] Flandre, Denis [UCL]

Achieving fast, sensitive and selective detection of bacteria in liquid samples is a major challenge for public healthcare. Unlike conventional methods, CMOS chips with sensing parts provide tremendous benefits in term of portability, system integration and reduced cost. CMOS-compatible microelectrodes were shown to selectively detect whole-cell Staphylococci after drying the sensor surface1. Here, we extend the use of these microelectrodes to bacteria detection in continuous flow for microfluidic applications.