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Direct-acting antivirals for paediatric HCV: we got there

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Sokal, Etienne [UCL]

In a new report, adolescents with genotype 2 or 3 HCV infection who were given sofosbuvir and ribavirin showed a near 100% sustained virologic response. This study is the beginning of a new wave of treatments for paediatric HCV infection, forming part of a global strategy to eradicate viral hepatitis.

Document type Article de périodique (Journal article) – Article de recherche
Publication date 2017
Language Anglais
Journal information "Nature Reviews. Gastroenterology & Hepatology" - Vol. 14, no. 8, p. 452-453 (2017)
Peer reviewed yes
Publisher Nature Publishing Group ((United Kingdom) London)
issn 1759-5045
e-issn 1759-5053
Publication status Publié
Affiliations UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique
UCL - SSS/IREC/PEDI - Pôle de Pédiatrie
Links
  1. Wirth Stefan, Current treatment options and response rates in children with chronic hepatitis C, 10.3748/wjg.v18.i2.99
  2. Pawlotsky Jean-Michel, Feld Jordan J., Zeuzem Stefan, Hoofnagle Jay H., From non-A, non-B hepatitis to hepatitis C virus cure, 10.1016/j.jhep.2015.02.006
  3. Druyts Eric, Thorlund Kristian, Wu Ping, Kanters Steve, Yaya Sanni, Cooper Curtis L., Mills Edward J., Efficacy and Safety of Pegylated Interferon Alfa-2a or Alfa-2b Plus Ribavirin for the Treatment of Chronic Hepatitis C in Children and Adolescents: A Systematic Review and Meta-analysis, 10.1093/cid/cis1031
  4. EASL Recommendations on Treatment of Hepatitis C 2016, 10.1016/j.jhep.2016.09.001
  5. Bortolotti Flavia, Verucchi Gabriella, Cammà Calogero, Cabibbo Giuseppe, Zancan Lucia, Indolfi Giuseppe, Giacchino Raffaella, Marcellini Matilde, Marazzi Maria Grazia, Barbera Cristiana, Maggiore Giuseppe, Vajro Pietro, Bartolacci Samuela, Balli Fiorella, Maccabruni Anna, Guido Maria, Long-Term Course of Chronic Hepatitis C in Children: From Viral Clearance to End-Stage Liver Disease, 10.1053/j.gastro.2008.02.082
Bibliographic reference Sokal, Etienne. Direct-acting antivirals for paediatric HCV: we got there. In: Nature Reviews. Gastroenterology & Hepatology, Vol. 14, no. 8, p. 452-453 (2017)
Permanent URL http://hdl.handle.net/2078.1/186851