User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Providing both autologous and allogeneic hematopoietic stem cell transplants (HSCT) may have a stronger impact on the outcome of autologous HSCT in adult patients than activity levels or implementation of JACIE at Belgian transplant centres.

Primary tabs

download
  • Open access
  • PDF
  • 1.08 M
download
  • Open access
  • PDF
  • 893.17 K
Poirel, Hélène A Vanspauwen, Marijke Macq, Gilles De Geyndt, Anke Maertens, Johan Poire, Xavier [UCL] Graux, Carlos [UCL] Belgian Transplant Registry and the Belgian Haematological Society’s Transplant committee

While performance since the introduction of the JACIE quality management system has been shown to be improved for allogeneic hematopoietic stem cell transplants (HSCT), impact on autologous-HSCT remains unclear in Europe. Our study on 2697 autologous-HSCT performed in adults in 17 Belgian centres (2007-2013) aims at comparing the adjusted 1 and 3-yr survival between the different centres & investigating the impact of 3 centre-related factors on performance (time between JACIE accreditation achievement by the centre and the considered transplant, centre activity volume and type of HSCT performed by centres: exclusively autologous vs both autologous & allogeneic). We showed a relatively homogeneous performance between Belgian centres before national completeness of JACIE implementation. The 3 centre-related factors had a significant impact on the 1-yr survival, while activity volume and type of HSCT impacted the 3-yr survival of autologous-HSCT patients in univariable analyses. Only activity volume (impact on 1-yr survival only) and type of HSCT (impact on 1 and 3-yr survivals) remained significant in multivariable analysis. This is explained by the strong relationship between these 3 variables. An extended transplantation experience, i.e., performing both auto & allo-HSCT, appears to be a newly informative quality indicator potentially conveying a multitude of underlying complex factors.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2019
Language Anglais
Journal information "Bone marrow transplantation" - Vol. 54, no. 9, p. 1434-1442 (2019)
Peer reviewed yes
Publisher Nature Publishing Group ((United Kingdom) London)
issn 0268-3369
e-issn 1476-5365
Publication status Publié
Affiliations UCL - SSS/IREC/MONT - Pôle Mont Godinne
UCL - SSS/IREC/SLUC - Pôle St.-Luc
UCL - (MGD) Service d'hématologie
UCL - (SLuc) Service d'hématologie
Links
  1. Spivak Jerry L., Myeloproliferative Neoplasms, 10.1056/nejmra1406186
  2. Zahid Umar, Akbar Faisal, Amaraneni Akshay, Husnain Muhammad, Chan Onyee, Riaz Irbaz Bin, McBride Ali, Iftikhar Ahmad, Anwer Faiz, A Review of Autologous Stem Cell Transplantation in Lymphoma, 10.1007/s11899-017-0382-1
  3. Kipps Thomas J., Stevenson Freda K., Wu Catherine J., Croce Carlo M., Packham Graham, Wierda William G., O'Brien Susan, Gribben John, Rai Kanti, Chronic lymphocytic leukaemia, 10.1038/nrdp.2017.8
  4. Copelan Edward A., Hematopoietic Stem-Cell Transplantation, 10.1056/nejmra052638
  5. Passweg J R, Baldomero H, Bader P, Bonini C, Duarte R F, Dufour C, Gennery A, Kröger N, Kuball J, Lanza F, Montoto S, Nagler A, Snowden J A, Styczynski J, Mohty M, Use of haploidentical stem cell transplantation continues to increase: the 2015 European Society for Blood and Marrow Transplant activity survey report, 10.1038/bmt.2017.34
  6. Saba Nabil, Abraham Rick, Keating Armand, Overview of autologous stem cell transplantation, 10.1016/s1040-8428(00)00087-1
  7. Ljungman P, , Bregni M, Brune M, Cornelissen J, Witte T de, Dini G, Einsele H, Gaspar H B, Gratwohl A, Passweg J, Peters C, Rocha V, Saccardi R, Schouten H, Sureda A, Tichelli A, Velardi A, Niederwieser D, Allogeneic and autologous transplantation for haematological diseases, solid tumours and immune disorders: current practice in Europe 2009, 10.1038/bmt.2009.141
  8. Majhail Navneet S., Farnia Stephanie H., Carpenter Paul A., Champlin Richard E., Crawford Stephen, Marks David I., Omel James L., Orchard Paul J., Palmer Jeanne, Saber Wael, Savani Bipin N., Veys Paul A., Bredeson Christopher N., Giralt Sergio A., LeMaistre Charles F., Indications for Autologous and Allogeneic Hematopoietic Cell Transplantation: Guidelines from the American Society for Blood and Marrow Transplantation, 10.1016/j.bbmt.2015.07.032
  9. Sureda A, , Bader P, Cesaro S, Dreger P, Duarte R F, Dufour C, Falkenburg J H F, Farge-Bancel D, Gennery A, Kröger N, Lanza F, Marsh J C, Nagler A, Peters C, Velardi A, Mohty M, Madrigal A, Indications for allo- and auto-SCT for haematological diseases, solid tumours and immune disorders: current practice in Europe, 2015, 10.1038/bmt.2015.6
  10. Peters WP, Dansey R, Baynes RD. Autologous bone marrow and stem cell transplantation. In: Kufe DW, Pollock RE, Weichselbaum RR et al., editors. Holland-Frei Cancer Medicine. B.C. Decker; 2003.
  11. Champlin R. Hematopoietic cellular transplantation. In: Kufe DW, Pollock RE, Weichselbaum RR et al., editors. Holland-Frei Cancer Medicine. B.C. Decker; 2003.
  12. Kusnierz-Glaz C R, Schlegel P G, Wong R M, Schriber J R, Chao N J, Amylon M D, Hu W W, Negrin R S, Lee Y, Blume K G, Long G D, Influence of age on the outcome of 500 autologous bone marrow transplant procedures for hematologic malignancies., 10.1200/jco.1997.15.1.18
  13. Miller C B, Piantadosi S, Vogelsang G B, Marcellus D C, Grochow L, Kennedy M J, Jones R J, Impact of age on outcome of patients with cancer undergoing autologous bone marrow transplant., 10.1200/jco.1996.14.4.1327
  14. Blume Karl G., Thomas E.Donnall, A review of autologous hematopoietic cell transplantation, 10.1016/s1083-8791(00)70047-4
  15. Snowden J A, McGrath E, Duarte R F, Saccardi R, Orchard K, Worel N, Kuball J, Chabannon C, Mohty M, JACIE accreditation for blood and marrow transplantation: past, present and future directions of an international model for healthcare quality improvement, 10.1038/bmt.2017.54
  16. Gratwohl Alois, Brand Ronald, Niederwieser Dietger, Baldomero Helen, Chabannon Christian, Cornelissen Jan, de Witte Theo, Ljungman Per, McDonald Fiona, McGrath Eoin, Passweg Jakob, Peters Christina, Rocha Vanderson, Slaper-Cortenbach Ineke, Sureda Anna, Tichelli Andre, Apperley Jane, Introduction of a Quality Management System and Outcome After Hematopoietic Stem-Cell Transplantation, 10.1200/jco.2010.30.4121
  17. Gratwohl A., Brand R., McGrath E., van Biezen A., Sureda A., Ljungman P., Baldomero H., Chabannon C., Apperley J., , Use of the quality management system "JACIE" and outcome after hematopoietic stem cell transplantation, 10.3324/haematol.2013.096461
  18. Schetelig Johannes, de Wreede Liesbeth C., Andersen Niels S., Moreno Carol, van Gelder Michel, Vitek Antonin, Karas Michal, Michallet Mauricette, Machaczka Maciej, Gramatzki Martin, Beelen Dietrich, Finke Jürgen, Delgado Julio, Volin Liisa, Passweg Jakob, Dreger Peter, Schaap Nicolaas, Wagner Eva, Henseler Anja, van Biezen Anja, Bornhäuser Martin, Iacobelli Simona, Putter Hein, Schönland Stefan O., Kröger Nicolaus, , Centre characteristics and procedure-related factors have an impact on outcomes of allogeneic transplantation for patients with CLL: a retrospective analysis from the European Society for Blood and Marrow Transplantation (EBMT), 10.1111/bjh.14791
  19. Royal Decree amending article 20, § 1, a), of the annex to the Royal Decree of 14 September 1984 establishing the nomenclature of health care benefits, on compulsory insurance for health care and allowances. Belgisch Staatsblad / Moniteur Belge; 2012-12-06/09.
  20. Haematological malignancies in Belgium, Belgian Cancer Registry, Brussels 2015.
  21. Armand P., Kim H. T., Logan B. R., Wang Z., Alyea E. P., Kalaycio M. E., Maziarz R. T., Antin J. H., Soiffer R. J., Weisdorf D. J., Rizzo J. D., Horowitz M. M., Saber W., Validation and refinement of the Disease Risk Index for allogeneic stem cell transplantation, 10.1182/blood-2014-01-552984
  22. Dohner H., Estey E. H., Amadori S., Appelbaum F. R., Buchner T., Burnett A. K., Dombret H., Fenaux P., Grimwade D., Larson R. A., Lo-Coco F., Naoe T., Niederwieser D., Ossenkoppele G. J., Sanz M. A., Sierra J., Tallman M. S., Lowenberg B., Bloomfield C. D., Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet, 10.1182/blood-2009-07-235358
  23. Deeg H. J., Scott B. L., Fang M., Shulman H. M., Gyurkocza B., Myerson D., Pagel J. M., Platzbecker U., Ramakrishnan A., Radich J. P., Sandmaier B. M., Sorror M., Stirewalt D. L., Wilson W. A., Storb R., Appelbaum F. R., Gooley T., Five-group cytogenetic risk classification, monosomal karyotype, and outcome after hematopoietic cell transplantation for MDS or acute leukemia evolving from MDS, 10.1182/blood-2012-04-423046
  24. Greenberg P, Cox C, LeBeau MM, Fenaux P, Morel P, Sanz G, et al. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood. 1997;89:2079–88.
  25. Andersen P. K., Generalised linear models for correlated pseudo-observations, with applications to multi-state models, 10.1093/biomet/90.1.15
  26. Logan Brent R., Review of Multistate Models in Hematopoietic Cell Transplantation Studies, 10.1016/j.bbmt.2012.10.016
  27. HURVICH CLIFFORD M., TSAI CHIH-LING, Regression and time series model selection in small samples, 10.1093/biomet/76.2.297
  28. Logan Brent R., Nelson Gene O., Klein John P., Analyzing center specific outcomes in hematopoietic cell transplantation, 10.1007/s10985-008-9100-6
  29. Anthias C, Ethell M E, Potter M N, Madrigal A, Shaw B E, The impact of improved JACIE standards on the care of related BM and PBSC donors, 10.1038/bmt.2014.260
  30. Anthias Chloe, O'Donnell Paul V., Kiefer Deidre M., Yared Jean, Norkin Maxim, Anderlini Paolo, Savani Bipin N., Diaz Miguel A., Bitan Menachem, Halter Joerg P., Logan Brent R., Switzer Galen E., Pulsipher Michael A., Confer Dennis L., Shaw Bronwen E., European Group for Blood and Marrow Transplantation Centers with FACT-JACIE Accreditation Have Significantly Better Compliance with Related Donor Care Standards, 10.1016/j.bbmt.2015.11.009
  31. Snowden John A., Badoglio Manuela, Labopin Myriam, Giebel Sebastian, McGrath Eoin, Marjanovic Zora, Burman Joachim, Moore John, Rovira Montserrat, Wulffraat Nico M., Kazmi Majid, Greco Raffaella, Snarski Emilian, Kozak Tomas, Kirgizov Kirill, Alexander Tobias, Bader Peter, Saccardi Riccardo, Farge Dominique, Evolution, trends, outcomes, and economics of hematopoietic stem cell transplantation in severe autoimmune diseases, 10.1182/bloodadvances.2017010041
  32. Horowitz MM, Przepiorka D, Champlin RE, Gale RP, Gratwohl A, Herzig RH, et al. Should HLA-identical sibling bone marrow transplants for leukemia be restricted to large centers? Blood. 1992;79:2771–4.
  33. Hows J, Bradley BA, Gore S, Downie T, Howard M, Gluckman E. Prospective evaluation of unrelated donor bone marrow transplantation. The International Marrow Unrelated Search and Transplant (IMUST) Study. Bone Marrow Transplant. 1993;12:371–80.
  34. Matsuo K, Hamajima N, Morishima Y, Harada M, Hospital capacity and post-transplant survival after allogeneic bone marrow transplantation: analysis of data from the Japan Society for Hematopoietic Cell Transplantation, 10.1038/sj.bmt.1702681
  35. Frassoni Francesco, Labopin Myriam, Powles Ray, Mary Jean-Yves, Arcese William, Bacigalupo Andrea, Bunjes Donald, Gluckman Eliane, Ruutu Tapani, Schaefer Ulrich W, Sierra Jorge, Vernant Jean Paul, Willemze Roel, de Witte Theo, Transplantation Norbert Claude Gorin, Effect of centre on outcome of bone-marrow transplantation for acute myeloid leukaemia, 10.1016/s0140-6736(00)02137-1
  36. Loberiza F R, Serna D S, Horowitz M M, Rizzo J D, Transplant center characteristics and clinical outcomes after hematopoietic stem cell transplantation: what do we know, 10.1038/sj.bmt.1703873
  37. LeMaistre C. Fred, Loberiza Fausto R., What is quality in a transplant program?, 10.1016/j.bbmt.2004.12.329
  38. Gratwohl A, Sureda A, Baldomero H, Gratwohl M, Dreger P, Kröger N, et al. Joint Accreditation Committee (JACIE) of the International Society for Cellular Therapy (ISCT) and the European Society for Blood and Marrow Transplantation (EBMT) and the European Leukemia Net (ELN). Economics and outcome after hematopoietic stem cell transplantation: a retrospective cohort study. EBioMedicine. 2015;2:2101–9.
Bibliographic reference Poirel, Hélène A ; Vanspauwen, Marijke ; Macq, Gilles ; De Geyndt, Anke ; Maertens, Johan ; et. al. Providing both autologous and allogeneic hematopoietic stem cell transplants (HSCT) may have a stronger impact on the outcome of autologous HSCT in adult patients than activity levels or implementation of JACIE at Belgian transplant centres.. In: Bone marrow transplantation, Vol. 54, no. 9, p. 1434-1442 (2019)
Permanent URL http://hdl.handle.net/2078.1/213967