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Temocillin plasma and pancreatic tissue concentrations in a critically ill patient with septic shock.

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Ngougni Pokem, Perrin [UCL] Capron, Arnaud [UCL] Wallemacq, Pierre [UCL] Tulkens, Paul M. [UCL] Van Bambeke, Françoise [UCL] Laterre, Pierre-François [UCL]

Sir, Resistance of Gram-negative pathogens to current antibiotics has revived interest in earlier and often disused molecules for which resistance is still low. Yet, detailed pharmacokinetic/pharmacodynamic data are scarce for these drugs. A typical example is temocillin (6-α-methoxy-ticarcillin), active against most Gram-negative bacteria, which shows stability against a variety of β-lactamases, including most ESBLs, AmpC and some carbapenemases. Temocillin represents a strategic sparing alternative to carbapenems.1 There is no EUCAST breakpoint set for temocillin, but in recent surveys, MIC90 values of 8–16 mg/L were reported for ESBL and AmpC producers [...]

Document type Article de périodique (Journal article) – Lettre à l'éditeur
Access type Accès libre
Publication date 2019
Language Anglais
Journal information "The Journal of antimicrobial chemotherapy" - Vol. 74, no.5, p. 1459–1461 (2019)
Peer reviewed yes
Publisher Oxford University Press ((United Kingdom) Oxford)
issn 0305-7453
e-issn 1460-2091
Publication status Publié
Affiliations UCL - SSS/IREC/MEDA - Pôle de médecine aiguë
UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology
UCL - SSS/LDRI - Louvain Drug Research Institute
UCL - (SLuc) Service de biochimie médicale
UCL - (SLuc) Service de soins intensifs
Keywords Septic shock ; Critical illness ; Plasma ; Pancreas
Links
  1. Livermore D. M., Tulkens P. M., Temocillin revived, 10.1093/jac/dkn511
  2. Alexandre K, Réveillon-Istin M, Fabre R, Delbos V, Etienne M, Pestel-Caron M, Dahyot S, Caron F, Temocillin against Enterobacteriaceae isolates from community-acquired urinary tract infections: low rate of resistance and good accuracy of routine susceptibility testing methods, 10.1093/jac/dky101
  3. Alexandre Kevin, Fantin Bruno, Pharmacokinetics and Pharmacodynamics of Temocillin, 10.1007/s40262-017-0584-7
  4. Delattre Isabelle K., Taccone Fabio S., Jacobs Frédérique, Hites Maya, Dugernier Thierry, Spapen Herbert, Laterre Pierre-François, Wallemacq Pierre E., Van Bambeke Françoise, Tulkens Paul M., Optimizing β-lactams treatment in critically-ill patients using pharmacokinetics/pharmacodynamics targets: are first conventional doses effective?, 10.1080/14787210.2017.1338139
  5. Tam Vincent H., Chang Kai-Tai, Zhou Jian, Ledesma Kimberly R., Phe Kady, Gao Song, Van Bambeke Françoise, Sánchez-Díaz Ana María, Zamorano Laura, Oliver Antonio, Cantón Rafael, Determining β-lactam exposure threshold to suppress resistance development in Gram-negative bacteria, 10.1093/jac/dkx001
  6. Laterre P.-F., Wittebole X., Van de Velde S., Muller A. E., Mouton J. W., Carryn S., Tulkens P. M., Dugernier T., Temocillin (6 g daily) in critically ill patients: continuous infusion versus three times daily administration, 10.1093/jac/dku465
  7. Ngougni Pokem Perrin, Miranda Bastos Ana C., Tulkens Paul M., Wallemacq Pierre, Van Bambeke Françoise, Capron Arnaud, Validation of a HPLC-MS/MS assay for the determination of total and unbound concentration of temocillin in human serum, 10.1016/j.clinbiochem.2015.02.006
  8. Caglar Veli, Kumral Bahadır, Uygur Ramazan, Alkoc Ozan Alper, Ozen Oguz Aslan, Demirel Husrev, Study of Volume, Weight and Size of Normal Pancreas, Spleen and Kidney in Adults Autopsies, 10.4236/fmar.2014.23012
  9. Deitchman Amelia N., Singh Ravi Shankar Prasad, Derendorf Hartmut, Nonlinear Protein Binding: Not What You Think, 10.1016/j.xphs.2018.03.023
Bibliographic reference Ngougni Pokem, Perrin ; Capron, Arnaud ; Wallemacq, Pierre ; Tulkens, Paul M. ; Van Bambeke, Françoise ; et. al. Temocillin plasma and pancreatic tissue concentrations in a critically ill patient with septic shock.. In: The Journal of antimicrobial chemotherapy, Vol. 74, no.5, p. 1459–1461 (2019)
Permanent URL http://hdl.handle.net/2078.1/218318