User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Neonatal acute myeloid leukemia in an infant whose mother was exposed to diethylstilboestrol in utero.

Primary tabs

Chantrain, Christophe [UCL] Sauvage, Delphine [UCL] Brichard, Bénédicte [UCL] Dupont, Serge [UCL] Poirel, Hélène [UCL] Ameye, Geneviève [UCL] Vandenberghe, Peter [UCL] Detaille, Thierry [UCL] Anslot, Christine [UCL] Clément de Cléty, Stephan [UCL] Vermylen, Christiane [UCL]

We report on an acute myeloid leukemia in a neonate whose mother was exposed to diethylstilboestrol in utero. The newborn presented with leukemia cutis, hemorrhagic skin lesions, hyperleucocytosis and disseminated intravascular coagulation. A bone marrow examination confirmed the diagnosis of acute monocytic leukemia with a t(11;19) MLL-ELL fusion transcript. Chemotherapy was initiated but the child developed a bilateral pulmonary infection that led to fatal respiratory distress. This case shows acute myeloid leukemia and the third pediatric leukemia reported after maternal diethylstilboestrol exposure. Pediatr Blood Cancer (c) 2009 Wiley-Liss, Inc.

  1. Herbst, Pediatrics, 62, 1151 (1978)
  2. Troisi, Int J Cancer, 121, 356 (2007)
  3. Giusti Ruthann M., Diethylstilbestrol Revisited: A Review of the Long-Term Health Effects, 10.7326/0003-4819-122-10-199505150-00008
  4. Newbold, Endocrinology, 147, S11 (2006)
  5. Titus-Ernstoff, Epidemiology, 19, 251 (2008)
  6. Zweidler-McKay, Curr Probl Pediatr Adolesc Health Care, 38, 78 (2008)
  7. Felix, Oncologist, 4, 225 (1999)
  8. Chowdhury, Blood Cells Mol Dis, 40, 192 (2008)
  9. Zeltzer, Am J Pediatr Hematol Oncol, 5, 315 (1983)
  10. Zeltzer, Am J Pediatr Hematol Oncol, 8, 275 (1986)
  11. Dou, Int J Hematol, 87, 10 (2008)
  12. Milne, Cancer Res, 65, 11367 (2005)
  13. Block, FASEB J, 14, 1101 (2000)
Bibliographic reference Chantrain, Christophe ; Sauvage, Delphine ; Brichard, Bénédicte ; Dupont, Serge ; Poirel, Hélène ; et. al. Neonatal acute myeloid leukemia in an infant whose mother was exposed to diethylstilboestrol in utero.. In: Pediatric Blood & Cancer, Vol. 53, no. 2, p. 220-222 (2009)
Permanent URL http://hdl.handle.net/2078.1/22320