Investigation of malignant cells in ovarian tissue from a patient with central nervous system primitive neuroectodermal tumor relapse after ovarian tissue transplantation

Nguyen, Thi Yen Thu [UCL] Camboni, Alessandra [UCL] Masciangelo, Rossella [UCL] Donnez, Jacques Dolmans, Marie-Madeleine [UCL]

(eng) Sir, Safety issues surrounding reimplantation of ovarian tissue retrieved at the time of a cancer diagnosis have been a cause of concern for many years.1-3 Here, we report a case of a central nervous system (CNS) primitive neuroectodermal tumor (PNET) relapse 6 years after ovarian tissue transplantation. In 2001, a 17-year-old patient was diagnosed with supratentorial PNET on the right orbitofrontal lobe of the cerebrum and underwent two operations for tumor removal. Prior to adjuvant chemotherapy, ovarian tissue biopsy and cryopreservation by slow-freezing were carried out, and no malignant cells were detected in the retrieved ovarian tissue. Follicle density (primordial follicles/mm3) was 55.7 ± 14.6 (SD). [...]