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ADVANCED DIFFUSION IMAGING METHODS TO ASSESS THE MICROSTRUCTURE OF MULTIPLE SCLEROSIS LESIONS

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Stölting, Anna [UCL] Vanden Bulcke, Colin [UCL] Macq, Benoît [UCL] Maggi, Pietro [UCL]

Paramagnetic Rim Lesions (PRL) in Multiple Sclerosis (MS) are associated with increased disability and axonal damage. We examined PRL microstructure using Track Density Imaging (TDI) and four diffusion MRI (dMRI) models, including Microstructure Fingerprinting (MF). When compared to non-PRL, PRL showed larger size, higher T1-values, lower neurite density index and fibre volume fraction on dMRI (p < 0.001) and reduced track density on TDI (p < 0.0001), suggesting impaired axonal density/integrity in PRL. Results obtained with the novel MF model are in line with those obtained with other dMRI models, indicating its potential for studying MS lesion pathology.

Document type Communication à un colloque (Conference Paper) – Présentation orale avec comité de sélection
Access type Accès libre
Publication date 2023
Language Anglais
Conference "International Society for Magnetic Resonance in Medicine (ISMRM)", Toronto (du 03/06/2023 au 08/06/2023)
Journal information "Proc. Intl. Soc. Mag. Reson. Med. 31 (2023)" - (19 May 2023)
Peer reviewed yes
issn 1545-4428
Affiliations UCL - SSS/IONS/NEUR - Clinical Neuroscience
UCL - SST/ICTM/ELEN - Pôle en ingénierie électrique
Keywords MRI ; Multiple Sclerosis ; Diffusion MRI ; Imaging Biomarker ; Chronic Active Lesions
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Bibliographic reference Stölting, Anna ; Vanden Bulcke, Colin ; Macq, Benoît ; Maggi, Pietro. ADVANCED DIFFUSION IMAGING METHODS TO ASSESS THE MICROSTRUCTURE OF MULTIPLE SCLEROSIS LESIONS.International Society for Magnetic Resonance in Medicine (ISMRM) (Toronto, du 03/06/2023 au 08/06/2023). In: Proc. Intl. Soc. Mag. Reson. Med. 31 (2023), (19 May 2023)
Permanent URL http://hdl.handle.net/2078.1/276351