Management of the Neck in Well-Differentiated Thyroid Cancer.

Asimakopoulos, Panagiotis Shaha, Ashok R Nixon, Iain J Shah, Jatin P Randolph, Gregory W Angelos, Peter Zafereo, Mark E Kowalski, Luiz P Hartl, Dana M Olsen, Kerry D Rodrigo, Juan P Vander Poorten, Vincent Mäkitie, Antti A Sanabria, Alvaro Suárez, Carlos Quer, Miquel Civantos, Francisco J Robbins, K Thomas Guntinas-Lichius, Orlando Hamoir, Marc [UCL] Rinaldo, Alessandra Ferlito, Alfio et al.[show all]

In this narrative review, we discuss the indications for elective and therapeutic neck dissections and the postoperative surveillance and treatment options for recurrent nodal disease in patients with well-differentiated thyroid cancer. Increased availability of advanced imaging modalities has led to an increased detection rate of previously occult nodal disease in thyroid cancer. Nodal metastases are more common in young patients, large primary tumors, specific genotypes, and certain histological types. While clinically evident nodal disease in the lateral neck compartments has a significant oncological impact, particularly in the older age group, microscopic metastases to the central or the lateral neck in well-differentiated thyroid cancer do not significantly affect outcome. As patients with clinically evident nodal disease are associated with worse outcomes, they should be treated surgically in order to reduce rates of regional recurrence and improve survival. The benefit of elective neck dissection remains unverified as the impact of microscopic disease on outcomes is not significant.