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Copper-Catalyzed Radical Cascade Annulation for the Preparation of Difluorinated Pyrrolidines and Piperidines

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Riant, Olivier [UCL] Marchese, Michela Maria [UCL] Strähler, Sebastian [UCL] Ghiba, Lucian [UCL]

In this work, we developed a one-pot, copper-catalyzed aminodifluoroalkylation of enylaniline derivatives. This approach allows the catalytic construction of a broad range of pyrrolidines and piperidines substituted with a gem-difluoro moiety.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2023
Language Anglais
Journal information "Synthesis" - Vol. 55, no.12, p. 1886-1892 (2022)
Peer reviewed yes
Publisher Georg Thieme Verlag KG
issn 0039-7881
e-issn 1437-210X
Publication status Publié
Affiliation UCL - SST/IMCN/MOST - Molecular Chemistry, Materials and Catalysis
Keywords Organic Chemistry ; Catalysis ; pyrrolidine ; piperidine ; heterocycles ; copper ; fluorine ; catalysis
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Bibliographic reference Riant, Olivier ; Marchese, Michela Maria ; Strähler, Sebastian ; Ghiba, Lucian. Copper-Catalyzed Radical Cascade Annulation for the Preparation of Difluorinated Pyrrolidines and Piperidines. In: Synthesis, Vol. 55, no.12, p. 1886-1892 (2022)
Permanent URL http://hdl.handle.net/2078.1/286980