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An animal model for anaplastic large cell lymphoma in the immunocompetent syngeneic C57Bl/6 mouse.

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Bittner, C [] Feller, A C [] Renauld, Jean-Christophe [UCL] Lange, K [] Pietrzik, R [] Merz, H []

We report on the analysis of a murine anaplastic lymphoid cell line TS1G6, established recently by interleukin (IL)-9 transfection. TS1G6 revealed a highly characteristic pattern of large anaplastic cells with mononuclear, binuclear, or multinuclear cells resembling Hodgkin (H) or Sternberg-Reed (SR) cells. This cell line is tumorigenous after injection of as few as 10(4) lymphoma cells into nude or immunocompetent C57Bl/6 mice and leads to death from progressive disease of all treated animals within a few weeks. The histological analysis of these tumors revealed a diffuse large cell malignant lymphoma that is morphologically almost identical to human anaplastic large cell lymphoma (ALCL). The lymphoma cells did not show overexpression of the anaplastic lymphoma kinase (ALK) gene, which is found in about 50% of the cases of human ALCL. Thus, this model may be an animal model for an important subset of human ALCL. The cytokine profile, which is of the T helper 2 type, showed strong parallels to the human lymphoma counterpart. Mice suffering from such lymphomas could not be cured with a regimen using high dose cyclophosphamide similar to many ALCL patients. Such an animal model for ALCL has not yet been recognized, but may provide the basis for investigating new antitumor immunotherapies in a fully immunocompetent host.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
Access type Accès restreint
Publication date 2000
Language Anglais
Journal information "Laboratory investigation; a journal of technical methods and pathology" - Vol. 80, no. 10, p. 1523-31 (2000)
Peer reviewed yes
issn 0023-6837
Publication status Publié
Affiliation UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique
MESH Subject Animals ; Antigens, CD30 - analysis ; Mice, Inbred C57BL ; Protein-Tyrosine Kinases - analysis ; RNA, Messenger - analysis ; Reverse Transcriptase Polymerase Chain Reaction ; Cyclophosphamide - therapeutic use ; Cytokines - genetics ; Disease Models, Animal ; Female ; Humans ; Immunohistochemistry ; Lymphoma, Large B-Cell, Diffuse - drug therapy, immunology, pathology ; Mice
Links
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Bibliographic reference Bittner, C ; Feller, A C ; Renauld, Jean-Christophe ; Lange, K ; Pietrzik, R ; et. al. An animal model for anaplastic large cell lymphoma in the immunocompetent syngeneic C57Bl/6 mouse.. In: Laboratory investigation; a journal of technical methods and pathology, Vol. 80, no. 10, p. 1523-31 (2000)
Permanent URL http://hdl.handle.net/2078.1/83959