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Management and palliative chemotherapy for metastatic or recurrent squamous cell carcinoma of the head and neck

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Machiels, Jean-Pascal [UCL] Schmitz, Sandra [UCL]

Squamous cell carcinoma of the head and neck with distant metastases or locoregional relapse not amenable to radical surgery or radiation therapy are incurable. Median overall survival is approximately 10 months and the site of relapse, frequently in the head and neck area, is responsible for important local and regional complications that significantly impact quality of life. This article will focus on the general management and treatment of these recurrent and/or metastatic patients. We will discuss the challenges faced by the clinician when diagnosing tumor recurrence, as well as the indications and the limitations of the locoregional and systemic treatments available to treat this population.

Document type Article de périodique (Journal article) – Synthèse de littérature – Journal Article, Review
Publication date 2011
Language Anglais
Journal information "Expert Review of Anticancer Therapy" - Vol. 11, no. 3, p. 359-371 (2011)
Peer reviewed yes
Publisher Expert Reviews Ltd. ((United Kingdom) London)
issn 1473-7140
e-issn 1744-8328
Publication status Publié
Affiliations UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie
UCL - Service d'oto-rhino-laryngologie
UCL - (SLuc) Unité d'oncologie médicale
MESH Subject Antineoplastic Agents - therapeutic use ; Carcinoma, Squamous Cell - drug therapy, pathology ; Head and Neck Neoplasms - drug therapy, pathology ; Humans ; Neoplasm Metastasis ; Palliative Care ; Recurrence
Links
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Bibliographic reference Machiels, Jean-Pascal ; Schmitz, Sandra. Management and palliative chemotherapy for metastatic or recurrent squamous cell carcinoma of the head and neck. In: Expert Review of Anticancer Therapy, Vol. 11, no. 3, p. 359-371 (2011)
Permanent URL http://hdl.handle.net/2078.1/88579