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Comparable High Rates of Extended-Spectrum-Beta-Lactamase-Producing Escherichia coli in Birds of Prey from Germany and Mongolia

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Guenther, S. Aschenbrenner, K. Stamm, I. Bethe, A. Semmler, T. Glupczynski, Gerald [UCL] Ewers, C.

Frequent contact with human waste and liquid manure from intensive livestock breeding, and the increased loads of antibiotic-resistant bacteria that result, are believed to be responsible for the high carriage rates of ESBL-producing E. coli found in birds of prey (raptors) in Central Europe. To test this hypothesis against the influence of avian migration, we initiated a comparative analysis of faecal samples from wild birds found in Saxony-Anhalt in Germany and the Gobi-Desert in Mongolia, regions of dissimilar human and livestock population characteristics and agricultural practices. We sampled a total of 281 wild birds, mostly raptors with primarily north-to-south migration routes. We determined antimicrobial resistance, focusing on ESBL production, and unravelled the phylogenetic and clonal relatedness of identified ESBL-producing E. coli isolates using multi-locus sequence typing (MLST) and macrorestriction analyses. Surprisingly, the overall carriage rates (approximately 5%) and the proportion of ESBL-producers among E. coli (Germany: 13.8%, Mongolia: 10.8%) were similar in both regions. Whereas blaCTX-M-1 predominated among German isolates (100%), blaCTX-M-9 was the most prevalent in Mongolian isolates (75%). We identified sequence types (STs) that are well known in human and veterinary clinical ESBL-producing E. coli (ST12, ST117, ST167, ST648) and observed clonal relatedness between a Mongolian avian ESBL-E. coli (ST167) and a clinical isolate of the same ST that originated in a hospitalised patient in Europe. Our data suggest the influence of avian migratory species in the transmission of ESBL-producing E. coli and challenge the prevailing assumption that reducing human influence alone invariably leads to lower rates of antimicrobial resistance. © 2012 Guenther et al.

Document type Article de périodique (Journal article)
Access type Accès libre
Publication date 2012
Language Anglais
Journal information "PLoS One" - Vol. 7, no.12, p. e53039 (2012)
Peer reviewed yes
Publisher Public Library of Science ((United States) [S.l.])
e-issn 1932-6203
Publication status Publié
Affiliation UCL - Autre
Links
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Bibliographic reference Guenther, S. ; Aschenbrenner, K. ; Stamm, I. ; Bethe, A. ; Semmler, T. ; et. al. Comparable High Rates of Extended-Spectrum-Beta-Lactamase-Producing Escherichia coli in Birds of Prey from Germany and Mongolia. In: PLoS One, Vol. 7, no.12, p. e53039 (2012)
Permanent URL http://hdl.handle.net/2078/132637