Journal Article

PreJuSER-62829

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The Alzheimer's beta amyloid (A beta {1-39} monomer in an implicit solvent

Anand, P.FZJ* ; Nandel, N. S. ; Hansmann, U. H. E.FZJ*

2008
American Institute of Physics Melville, NY

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Please use a persistent id in citations: http://hdl.handle.net/2128/19028  doi:10.1063/1.2907718

Abstract: Results from replica-exchange and regular room temperature molecular dynamics simulations of the Alzheimer's beta amyloid (Abeta(1-39)) monomer in an implicit solvent are reported. Our data indicate that at room temperature, the monomer assumes random-coil and soluble conformations. No beta content is observed which therefore seems to be a product of oligomerization and aggregation of monomers.

Keyword(s): Amyloid beta-Peptides: chemistry (MeSH) ; Amyloid beta-Peptides: ultrastructure (MeSH) ; Computer Simulation (MeSH) ; Models, Chemical (MeSH) ; Models, Molecular (MeSH) ; Protein Conformation (MeSH) ; Solvents: chemistry (MeSH) ; Amyloid beta-Peptides ; Solvents ; J

Note: Record converted from VDB: 12.11.2012

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Contributing Institute(s):

1. John von Neumann - Institut für Computing (NIC)

Research Program(s):

1. Scientific Computing (P41)

Appears in the scientific report 2008

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Database coverage:

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