A tale of 3 tracers : contrasting uptake patterns of 18F-fluciclovine, 68Ga-PSMA, and 18F-FDG in the uterus and adnexa
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Date
Authors
Lawal, Ismaheel Opeyemi
Adediran, Omotayo Atinuke
Muzahir, Saima
Friend, Sarah
Bhave, Manali Ajay
Meisel, Jane
Torres, Mylin A.
Styblo, Toncred Marya
Graham, Cathy
Holbrook, Anna
Journal Title
Journal ISSN
Volume Title
Publisher
Lippincott Williams and Wilkins
Abstract
A 41-year-old woman with newly diagnosed invasive lobular carcinoma of the breast underwent sequential 68Ga-PSMA-11 PET/CT and 18F-fluciclovine PET/CT as part of an ongoing clinical trial (NCT04750473). 68Ga-PSMA PET/CT showed increased radiotracer uptake in the uterine endometrium and left adnexa. 18F-fluciclovine PET/CT showed increased radiotracer uptake in an enlarged uterus in a known uterine leiomyoma. A clinical 18F-FDG PET/CT demonstrated radiotracer uptake in the endometrium and a circumferential area of uptake in the left adnexa, a pattern more similar to the 68Ga-PSMA uptake pattern. This case highlights the discordance in the uptake pattern of two radiotracers in different benign gynecological conditions. While these tracers are approved for prostate cancer imaging, they are increasingly being used in other malignancies.
Description
Keywords
68Ga-PSMA PET, Positron emission tomography/computed tomography (PET/CT), Positron emission tomography (PET), 18F-fluciclovin PET, Uterine leiomyoma, Luteal cyst, Endometrium, Adnexa mass, SDG-03: Good health and well-being
Sustainable Development Goals
Citation
Lawal, I.O., Adediran, O.A., Muzahir, S. et al. 2023, 'A tale of 3 tracers: contrasting uptake patterns of 18F-fluciclovine, 68Ga-PSMA, and 18F-FDG in the uterus and adnexa', Clinical Nuclear Medicine, vol. 48, no. 1, pp. E26-E27, doi : 10.1097/RLU.0000000000004385.