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ファイル | 記述 | サイズ | フォーマット | |
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j.cmet.2011.05.011.pdf | 3.46 MB | Adobe PDF | 見る/開く |
タイトル: | TRIC-A Channels in Vascular Smooth Muscle Contribute to Blood Pressure Maintenance. |
著者: | Yamazaki, Daiju Tabara, Yasuharu Kita, Satomi Hanada, Hironori Komazaki, Shinji Naitou, Daisuke Mishima, Aya Nishi, Miyuki Yamamura, Hisao Yamamoto, Shinichiro Kakizawa, Sho https://orcid.org/0000-0001-8396-5411 (unconfirmed) Miyachi, Hitoshi Yamamoto, Shintaro Miyata, Toshiyuki Kawano, Yuhei Kamide, Kei Ogihara, Toshio Hata, Akira Umemura, Satoshi Soma, Masayoshi Takahashi, Norio Imaizumi, Yuji Miki, Tetsuro Iwamoto, Takahiro Takeshima, Hiroshi https://orcid.org/0000-0003-4525-3725 (unconfirmed) |
発行日: | 3-Aug-2011 |
出版者: | Elsevier BV |
引用: | Yamazaki D, Tabara Y, Kita S, Hanada H, Komazaki S, Naitou D, Mishima A, Nishi M, Yamamura H, Yamamoto S, Kakizawa S, Miyachi H, Yamamoto S, Miyata T, Kawano Y, Kamide K, Ogihara T, Hata A, Umemura S, Soma M, Takahashi N, Imaizumi Y, Miki T, Iwamoto T, Takeshima H. TRIC-A Channels in Vascular Smooth Muscle Contribute to Blood Pressure Maintenance. Cell Metab. 2011 Aug 3;14(2):231-41. |
誌名: | Cell metabolism |
巻: | 14 |
号: | 2 |
開始ページ: | 231 |
終了ページ: | 241 |
抄録: | TRIC channel subtypes, namely TRIC-A and TRIC-B, are intracellular monovalent cation channels postulated to mediate counter-ion movements facilitating physiological Ca(2+) release from internal stores. Tric-a-knockout mice developed hypertension during the daytime due to enhanced myogenic tone in resistance arteries. There are two Ca(2+) release mechanisms in vascular smooth muscle cells (VSMCs); incidental opening of ryanodine receptors (RyRs) generates local Ca(2+) sparks to induce hyperpolarization, while agonist-induced activation of inositol trisphosphate receptors (IP(3)Rs) evokes global Ca(2+) transients causing contraction. Tric-a gene ablation inhibited RyR-mediated hyperpolarization signaling to stimulate voltage-dependent Ca(2+) influx, and adversely enhanced IP(3)R-mediated Ca(2+) transients by overloading Ca(2+) stores in VSMCs. Moreover, association analysis identified single-nucleotide polymorphisms (SNPs) around the human TRIC-A gene that increase hypertension risk and restrict the efficiency of antihypertensive drugs. Therefore, TRIC-A channels contribute to maintaining blood pressure, while TRIC-A SNPs could provide biomarkers for constitutional diagnosis and personalized medical treatment of essential hypertension. |
記述: | 小胞体カウンターイオンチャネルTRICチャネルによる血圧調節機構とTRICチャネル遺伝子多型による本態性高血圧リスク. 京都大学プレスリリース. 2011-08-02. |
著作権等: | © 2011 Elsevier Inc. All rights reserved. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/143634 |
DOI(出版社版): | 10.1016/j.cmet.2011.05.011 |
PubMed ID: | 21803293 |
関連リンク: | http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B7MFH-53FSRYK-H-1&_cdi=23259&_user=119230&_pii=S1550413111002178&_origin=gateway&_coverDate=08%2F03%2F2011&_sk=%23TOC%2323259%232011%23999859997%233458964%23FLA%23display%23Volume_14, _Issue_2, _Pages_143-280_%283_August_2011%29%23tagged%23Volume%23first%3D14%23Issue%23first%3D2%23date%23%283_August_2011%29%23&view=c&_gw=y&wchp=dGLzVzb-zSkWW&md5=9d6681ac09f2dd2e8a01f6d241047443&ie=/sdarticle.pdf http://www.kyoto-u.ac.jp/ja/news_data/h/h1/news6/2011/110802_1.htm |
出現コレクション: | 学術雑誌掲載論文等 |
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