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タイトル: | Biomaterial-based delivery systems of nucleic acid for regenerative research and regenerative therapy |
著者: | Jo, Jun-ichiro Gao, Jian-Qing Tabata, Yasuhiko |
著者名の別形: | 城, 潤一郎 田畑, 泰彦 |
キーワード: | Biomaterials Drug delivery system Cell scaffold Nucleic acids Regenerative research Regenerative therapy |
発行日: | Dec-2019 |
出版者: | Elsevier BV |
誌名: | Regenerative Therapy |
巻: | 11 |
開始ページ: | 123 |
終了ページ: | 130 |
抄録: | Regenerative medicine is a new and promising medical method aiming at treating patients with defective or dysfunctional tissues by maintaining or enhancing the biological activity of cells. The development of biomaterial-based technologies, such as cell scaffolds and carriers for drug delivery system, are highly required to promote the regenerative research and regenerative therapy. Nucleic acids are one of the most feasible factors to efficiently modify the biological activity of cells. The effective and stable delivery of nucleic acids into cells is highly required to succeed in the modification. Biomaterials-based non-viral carriers or biological carriers, like exosomes, play an important role in the efficient delivery of nucleic acids. This review introduces the examples of regenerative research and regenerative therapy based on the delivery of nucleic acids with biomaterials technologies and emphasizes their importance to accomplish regenerative medicine. |
著作権等: | © 2019, The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
URI: | http://hdl.handle.net/2433/244156 |
DOI(出版社版): | 10.1016/j.reth.2019.06.007 |
PubMed ID: | 31338391 |
出現コレクション: | 学術雑誌掲載論文等 |
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