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タイトル: | Regulating divergent transcriptomes through mrna splicing and its modulation using various small compounds |
著者: | Fujita, Ken Ichi Ishizuka, Takaki Mitsukawa, Mizuki Kurata, Masashi Masuda, Seiji |
著者名の別形: | 藤田, 賢一 倉田, 雅志 増田, 誠司 |
キーワード: | alternative mRNA splicing cancer neurodegenerative disorder splicing inhibitor food-derived compound |
発行日: | Mar-2020 |
出版者: | MDPI AG |
誌名: | International Journal of Molecular Sciences |
巻: | 21 |
号: | 6 |
論文番号: | 2026 |
抄録: | Human transcriptomes are more divergent than genes and contribute to the sophistication of life. This divergence is derived from various isoforms arising from alternative splicing. In addition, alternative splicing regulated by spliceosomal factors and RNA structures, such as the RNA G-quadruplex, is important not only for isoform diversity but also for regulating gene expression. Therefore, abnormal splicing leads to serious diseases such as cancer and neurodegenerative disorders. In the first part of this review, we describe the regulation of divergent transcriptomes using alternative mRNA splicing. In the second part, we present the relationship between the disruption of splicing and diseases. Recently, various compounds with splicing inhibitor activity were established. These splicing inhibitors are recognized as a biological tool to investigate the molecular mechanism of splicing and as a potential therapeutic agent for cancer treatment. Food-derived compounds with similar functions were found and are expected to exhibit anticancer effects. In the final part, we describe the compounds that modulate the messenger RNA (mRNA) splicing process and their availability for basic research and future clinical potential. |
著作権等: | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
URI: | http://hdl.handle.net/2433/259325 |
DOI(出版社版): | 10.3390/ijms21062026 |
PubMed ID: | 32188117 |
出現コレクション: | 学術雑誌掲載論文等 |
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