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タイトル: | A simplified method to quantitatively predict the effect of lenvatinib on hepatocellular carcinoma using contrast-enhanced ultrasound with perfluorobutane microbubbles |
著者: | Eso, Yuji https://orcid.org/0000-0003-4426-1491 (unconfirmed) Nakano, Shigeharu Mishima, Masako Arasawa, Soichi Iguchi, Eriko Takeda, Haruhiko Takai, Atsushi Takahashi, Ken Seno, Hiroshi |
著者名の別形: | 惠莊, 裕嗣 中野, 重治 三嶋, 眞紗子 荒澤, 壮一 井口, 恵里子 竹田, 治彦 髙井, 淳 高橋, 健 妹尾, 浩 |
キーワード: | Contrast-enhanced ultrasound (CEUS) hepatocellular carcinoma (HCC) lenvatinib sonazoid time-intensity curve analysis |
発行日: | Jun-2021 |
出版者: | AME Publishing Company |
誌名: | Quantitative Imaging in Medicine and Surgery |
巻: | 11 |
号: | 6 |
開始ページ: | 2766 |
終了ページ: | 2774 |
抄録: | Contrast-enhanced computed tomography (CECT) is generally used to evaluate the response to treatment of hepatocellular carcinoma (HCC); however, CECT is unsuitable for the early prediction of therapeutic effects and frequent monitoring. We aimed to investigate the usefulness of our simplified method for the quantification of tumor vascularity using contrast-enhanced ultrasound (CEUS) with perfluorobutane microbubbles [Sonazoid® (GE Healthcare, Oslo, Norway)] to predict the therapeutic effect of lenvatinib. Among the 13 patients studied, nine who had more than a 20% reduction in tumor vascularity within 2 weeks of starting treatment experienced complete response or partial response at 8-12 weeks as assessed by CECT. In contrast, three patients without reductions and one patient with only a slight decrease in tumor vascularity had a poor response to lenvatinib. Quantitative assessment of tumor vascularity by our simplified CEUS-based method could be a useful predictor of therapeutic responses to lenvatinib in patients with HCC. |
著作権等: | © Quantitative Imaging in Medicine and Surgery. All rights reserved. This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license) |
URI: | http://hdl.handle.net/2433/276577 |
DOI(出版社版): | 10.21037/qims-20-965 |
PubMed ID: | 34079740 |
出現コレクション: | 学術雑誌掲載論文等 |
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