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タイトル: | The phosphorylated pathway of serine biosynthesis affects sperm, embryo, and sporophyte development, and metabolism in Marchantia polymorpha |
著者: | Wang, Mengyao Tabeta, Hiromitsu Ohtaka, Kinuka Kuwahara, Ayuko Nishihama, Ryuichi Ishikawa, Toshiki Toyooka, Kiminori Sato, Mayuko Wakazaki, Mayumi Akashi, Hiromichi Tsugawa, Hiroshi Shoji, Tsubasa Okazaki, Yozo Yoshida, Keisuke Sato, Ryoichi Ferjani, Ali Kohchi, Takayuki https://orcid.org/0000-0002-9712-4872 (unconfirmed) Hirai, Masami Yokota |
著者名の別形: | ワン, ムンヤオ 多部田, 弘光 大髙, きぬ香 桑原, 亜由子 西浜, 竜一 石川, 寿樹 豊岡, 公徳 佐藤, 繭子 若崎, 眞由美 明石, 寛道 津川, 裕司 庄司, 翼 岡咲, 洋三 吉田, 啓亮 佐藤, 諒一 フェルジャニ, アリ 河内, 孝之 平井, 優美 |
キーワード: | Plant development Plant physiology |
発行日: | 24-Jan-2024 |
出版者: | Springer Nature |
誌名: | Communications Biology |
巻: | 7 |
論文番号: | 102 |
抄録: | Serine metabolism is involved in various biological processes. Here we investigate primary functions of the phosphorylated pathway of serine biosynthesis in a non-vascular plant Marchantia polymorpha by analyzing knockout mutants of MpPGDH encoding 3-phosphoglycerate dehydrogenase in this pathway. Growth phenotypes indicate that serine from the phosphorylated pathway in the dark is crucial for thallus growth. Sperm development requires serine from the phosphorylated pathway, while egg formation does not. Functional MpPGDH in the maternal genome is necessary for embryo and sporophyte development. Under high CO2 where the glycolate pathway of serine biosynthesis is inhibited, suppressed thallus growth of the mutants is not fully recovered by exogenously-supplemented serine, suggesting the importance of serine homeostasis involving the phosphorylated and glycolate pathways. Metabolomic phenotypes indicate that the phosphorylated pathway mainly influences the tricarboxylic acid cycle, the amino acid and nucleotide metabolism, and lipid metabolism. These results indicate the importance of the phosphorylated pathway of serine biosynthesis in the dark, in the development of sperm, embryo, and sporophyte, and metabolism in M. polymorpha. |
著作権等: | © The Author(s) 2024 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. |
URI: | http://hdl.handle.net/2433/286779 |
DOI(出版社版): | 10.1038/s42003-023-05746-6 |
PubMed ID: | 38267515 |
出現コレクション: | 学術雑誌掲載論文等 |
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