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j.celrep.2023.113602.pdf | 9.38 MB | Adobe PDF | 見る/開く |
タイトル: | Selective induction of human renal interstitial progenitor-like cell lineages from iPSCs reveals development of mesangial and EPO-producing cells |
著者: | Tsujimoto, Hiraku Hoshina, Azusa Mae, Shin-Ichi Araoka, Toshikazu https://orcid.org/0000-0001-9101-9417 (unconfirmed) Changting, Wang Ijiri, Yoshihiro Nakajima-Koyama, May Sakurai, Satoko Okita, Kazusa Mizuta, Ken https://orcid.org/0000-0002-3922-1009 (unconfirmed) Niwa, Akira Saito, Megumu K. Saitou, Mitinori Yamamoto, Takuya https://orcid.org/0000-0002-0022-3947 (unconfirmed) Graneli, Cecilia Woollard, Kevin J. Osafune, Kenji https://orcid.org/0000-0001-7238-2763 (unconfirmed) |
著者名の別形: | 辻本, 啓 保科, あずさ 前, 伸一 荒岡, 利和 井尻, 芳弘 小山, 明 櫻井, 智子 水田, 賢 丹羽, 明 齋藤, 潤 斎藤, 通紀 山本, 拓也 長船, 健二 |
発行日: | 27-Feb-2024 |
出版者: | Elsevier BV |
誌名: | Cell Reports |
巻: | 43 |
号: | 2 |
論文番号: | 113602 |
抄録: | Recent regenerative studies using human pluripotent stem cells (hPSCs) have developed multiple kidney-lineage cells and organoids. However, to further form functional segments of the kidney, interactions of epithelial and interstitial cells are required. Here we describe a selective differentiation of renal interstitial progenitor-like cells (IPLCs) from human induced pluripotent stem cells (hiPSCs) by modifying our previous induction method for nephron progenitor cells (NPCs) and analyzing mouse embryonic interstitial progenitor cell (IPC) development. Our IPLCs combined with hiPSC-derived NPCs and nephric duct cells form nephrogenic niche- and mesangium-like structures in vitro. Furthermore, we successfully induce hiPSC-derived IPLCs to differentiate into mesangial and erythropoietin-producing cell lineages in vitro by screening differentiation-inducing factors and confirm that p38 MAPK, hypoxia, and VEGF signaling pathways are involved in the differentiation of mesangial-lineage cells. These findings indicate that our IPC-lineage induction method contributes to kidney regeneration and developmental research. |
記述: | ヒトiPS細胞から腎間質前駆細胞の選択的な分化誘導を経て、メサンギウム細胞とエリスロポエチン産生細胞を作製. 京都大学プレスリリース. 2024-01-18. Learning from renal development to generate better kidney organoids for regenerative medicine. 京都大学プレスリリース. 2024-01-18. |
著作権等: | © 2023 The Authors. This is an open access article under the CC BY license. |
URI: | http://hdl.handle.net/2433/287106 |
DOI(出版社版): | 10.1016/j.celrep.2023.113602 |
PubMed ID: | 38237600 |
関連リンク: | https://www.cira.kyoto-u.ac.jp/j/pressrelease/news/240118-010000.html https://www.cira.kyoto-u.ac.jp/e/pressrelease/news/240118-010000.html |
出現コレクション: | 学術雑誌掲載論文等 |
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