Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/190185
Title: | Evaluation of the inflammatory and osteogenic response induced by titanium particles released during implantoplasty of dental implants |
Author: | Toledano Serrabona, Jorge Bosch, Begoña M. Díez Tercero, Leire Gil, F. X. (Francesc Xavier) Camps Font, Octavi Valmaseda Castellón, Eduardo Gay Escoda, Cosme Sánchez Garcés, Ma. Ángeles |
Keywords: | Implants dentals Aliatges Dental implants Alloys |
Issue Date: | 22-Sep-2022 |
Publisher: | Springer Science and Business Media LLC |
Abstract: | Implantoplasty is a mechanical decontamination technique that consists of removing the threads and polishing and smoothing the dental implant surface. During implantoplasty there is a large release of titanium metal particles that might provoke a proinflammatory response and reduce the viability of osteogenic cells. We analyze the inflammatory and osteogenic response induced by Ti6Al4V particles released during implantoplasty and by as-received commercially pure Ti particles. Macrophages stimulated with metal particles obtained by implantoplasty and with as-received Ti particles showed an increased proinflammatory expression of TNF-alpha and a decreased expression of TGF-beta and CD206. Regarding cytokine release, there was an increase in IL-1 beta, while IL-10 decreased. The osteogenic response of Ti6Al4V extracts showed a significant decrease in Runx2 and OC expression compared to the controls and commercially pure Ti extracts. There were no relevant changes in ALP activity. Thus, implantoplasty releases metal particles that seems to induce a pro-inflammatory response and reduce the expression of osteogenic markers. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41598-022-20100-2 |
It is part of: | Scientific Reports, 2022, vol. 12, issue. 1 |
URI: | http://hdl.handle.net/2445/190185 |
Related resource: | https://doi.org/10.1038/s41598-022-20100-2 |
ISSN: | 2045-2322 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Odontoestomatologia) |
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s41598-022-20100-2.pdf | 1.39 MB | Adobe PDF | View/Open |
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