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Title: | Emerging issues on Staphylococcus aureus endocarditis and the role in therapy of daptomycin plus fosfomycin |
Author: | Garcia de la Mària, Cristina Cañas, María Alexandra Fernández Pittol, Mariana Dahl, Anders García González, Javier Hernández Meneses, Marta Cuervo Requena, Guillermo Moreno, Asunción Miro, José M. Marco, Francesc |
Keywords: | Medicaments antibacterians Endocarditis Antibacterial agents Endocarditis |
Issue Date: | 10-Feb-2023 |
Publisher: | Taylor and Francis |
Abstract: | IntroductionMethicillin-resistant and -susceptible Staphylococcus aureus (MRSA/MSSA) infections are a major global health-care problem. Bacteremia with S. aureus exhibits high rates of morbidity and mortality and can cause complicated infections such as infective endocarditis (IE). The emerging resistance profile of S. aureus is worrisome, and several international agencies have appealed for new treatment approaches to be developed.Areas coveredDaptomycin presents a rapid bactericidal effect against MRSA and has been considered at least as effective as vancomycin in treating MRSA bacteremia. However, therapy failure is often related to deep-seated infections, e.g. endocarditis, with high bacterial inocula and daptomycin regimens S. aureus infections have limitations in monotherapy. Daptomycin in combination with other antibiotics, e.g. fosfomycin, may be effective in improving clinical outcomes in patients with MRSA IE.Expert opinionExploring therapeutic combinations has shown fosfomycin to have a unique mechanism of action and to be the most effective option in preventing the onset of resistance to and optimizing the efficacy of daptomycin, suggesting the synergistic combination of fosfomycin with daptomycin is a useful alternative treatment option for MSSA or MRSA IE. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1080/14787210.2023.2174969 |
It is part of: | Expert Review Of Anti-Infective Therapy, 2023, vol. 21, num. 3, p. 281-293 |
URI: | http://hdl.handle.net/2445/206265 |
Related resource: | https://doi.org/10.1080/14787210.2023.2174969 |
ISSN: | 1744-8336 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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Emerging issues_merged.pdf | 476.56 kB | Adobe PDF | View/Open |
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