Body shape phenotypes of multiple anthropometric traits and cancer risk: a multi-national cohort study
Permanent lenke
https://hdl.handle.net/10037/28030Dato
2022-12-02Type
Journal articleTidsskriftartikkel
Peer reviewed
Forfatter
Sedlmeier, Anja M.; Viallon, Vivian; Ferrari, Pietro; Peruchet-Noray, Laia; Fontvieille, Emma; Amadou, Amina; Seyed Khoei, Nazlisadat; Weber, Andrea; Baurecht, Hansjörg; Heath, Alicia K.; Tsilidis, Kostas; Kaaks, Rudolf; Katzke, Verena; Inan-Eroglu, Elif; Schulze, Matthias B.; Overvad, Kim; Bonet, Catalina; Ubago-Guisado, Esther; Chirlaque, María-Dolores; Ardanaz, Eva; Perez-Cornago, Aurora; Pala, Valeria; Tumino, Rosario; Sacerdote, Carlotta; Pasanisi, Fabrizio; Borch, Kristin Benjaminsen; Rylander, Charlotta; Weiderpass, Elisabete; Gunter, Marc J.; Fervers, Béatrice; Leitzmann, Michael F.; Freisling, HeinzSammendrag
Methods - We derived four distinct body shape phenotypes from principal component (PC) analysis on height, weight, body mass index (BMI), waist (WC) and hip circumferences (HC), and waist-to-hip ratio (WHR). The study included 340,152 men and women from 9 European countries, aged mostly 35–65 years at recruitment (1990–2000) in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards regression was used to estimate multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs).
Results - After a median follow-up of 15.3 years, 47,110 incident cancer cases were recorded. PC1 (overall adiposity) was positively associated with the risk of overall cancer, with a HR per 1 standard deviation (SD) increment equal to 1.07 (95% confidence interval 1.05 to 1.08). Positive associations were observed with 10 cancer types, with HRs (per 1 SD) ranging from 1.36 (1.30–1.42) for endometrial cancer to 1.08 (1.03–1.13) for rectal cancer. PC2 (tall stature with low WHR) was positively associated with the risk of overall cancer (1.03; 1.02–1.04) and five cancer types which were not associated with PC1. PC3 (tall stature with high WHR) was positively associated with the risk of overall cancer (1.04; 1.03–1.05) and 12 cancer types. PC4 (high BMI and weight with low WC and HC) was not associated with overall risk of cancer (1.00; 0.99–1.01).
Conclusions - In this multi-national study, distinct body shape phenotypes were positively associated with the incidence of 17 different cancers and overall cancer.