Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/106505
Título: | Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia | Autor: | Llorens, Franc Hermann, Peter Villar-Piqué, Anna Diaz-Lucena, Daniela Nägga, Katarina Hansson, Oskar Santana, Isabel Schmitz, Matthias Schmidt, Christian Varges, Daniela Goebel, Stefan Dumurgier, Julien Zetterberg, Henrik Blennow, Kaj Paquet, Claire Baldeiras, Inês Ferrer, Isidro Zerr, Inga |
Data: | 30-Jan-2020 | Editora: | Springer Nature | Título da revista, periódico, livro ou evento: | Nature Communications | Volume: | 11 | Número: | 1 | Resumo: | The clinical diagnosis of vascular dementia (VaD) is based on imaging criteria, and specific biochemical markers are not available. Here, we investigated the potential of cerebrospinal fluid (CSF) lipocalin 2 (LCN2), a secreted glycoprotein that has been suggested as mediating neuronal damage in vascular brain injuries. The study included four independent cohorts with a total n = 472 samples. LCN2 was significantly elevated in VaD compared to controls, Alzheimer's disease (AD), other neurodegenerative dementias, and cognitively unimpaired patients with cerebrovascular disease. LCN2 discriminated VaD from AD without coexisting VaD with high accuracy. The main findings were consistent over all cohorts. Neuropathology disclosed a high percentage of macrophages linked to subacute infarcts, reactive astrocytes, and damaged blood vessels in multi-infarct dementia when compared to AD. We conclude that CSF LCN2 is a promising candidate biochemical marker in the differential diagnosis of VaD and neurodegenerative dementias. | URI: | https://hdl.handle.net/10316/106505 | ISSN: | 2041-1723 | DOI: | 10.1038/s41467-020-14373-2 | Direitos: | openAccess |
Aparece nas coleções: | FMUC Medicina - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Cerebrospinal-fluid-lipocalin-2-as-a-novel-biomarker-for-the-differential-diagnosis-of-vascular-dementiaNature-Communications.pdf | 3.08 MB | Adobe PDF | Ver/Abrir |
Citações WEB OF SCIENCETM
50
Visto em 2/mai/2023
Visualizações de página
48
Visto em 8/mai/2024
Downloads
10
Visto em 8/mai/2024
Google ScholarTM
Verificar
Altmetric
Altmetric
Este registo está protegido por Licença Creative Commons