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https://hdl.handle.net/10316/27430
Title: | Pd/C-mediated synthesis of (Z)-3-alkylidenephthalides of potential pharmacological interest | Authors: | Rambabu, D. Kumar, G. Pavan Kumar, Barange Deepak Kapavarapu, Ravikumar Rao, M. V. Basaveswara Pal, Manojit |
Keywords: | Alkynes; Pd/C; Coupling; 3-Alkylidenephthalides | Issue Date: | 5-Jun-2013 | Publisher: | Elsevier | Citation: | RAMBABU, D. [et. al] - Pd/C-mediated synthesis of (Z)-3-alkylidenephthalides of potential pharmacological interest. "Tetrahedron Letters". ISSN 0040-4039. Vol. 54 Nº. 23 (2013) p. 2989-2995 | Serial title, monograph or event: | Tetrahedron Letters | Volume: | 54 | Issue: | 23 | Abstract: | The coupling of o-bromobenzoic acid with terminal alkynes using 10% Pd/C–Et3N–CuI–PPh3 as a catalyst system leads to the synthesis of (Z)-3-alkylidenephthalides as the major product along with the traces of isocoumarin when the reaction was performed in 1,4-dioxane. The methodology afforded a range of compounds including (Z)-3-(4-(methylsulfonyl)benzylidene)isobenzofuran-1(3H)-one of potential pharmacological interest. | URI: | https://hdl.handle.net/10316/27430 | ISSN: | 0040-4039 | DOI: | 10.1016/j.tetlet.2013.03.121 | Rights: | openAccess |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
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