Novel ways to target brain tumour metabolism.

Stieber, Daniel; Abdul Rahim, Siti A; NICLOU, Simone P.

doi:10.1517/14728222.2011.588211

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Novel ways to target brain tumour metabolism.

Stieber, Daniel; Abdul Rahim, Siti A; NICLOU, Simone P.

2011 • In Expert Opinion on Therapeutic Targets, 15 (10), p. 1227-39

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https://hdl.handle.net/10993/60313

DOI
10.1517/14728222.2011.588211

PubMed
21635150

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Keywords :

EC 1.1.1.41 (Isocitrate Dehydrogenase); Brain Neoplasms/enzymology/metabolism/pathology; Glioblastoma/enzymology/metabolism/pathology; Humans; Isocitrate Dehydrogenase/genetics/metabolism; Mutation

Abstract :

[en] INTRODUCTION: Glioblastoma remains a highly aggressive primary brain cancer with very poor prognosis. The detection of mutations in the metabolic enzyme isocitrate dehydrogenase in gliomas, has broadened our view of tumourigenic mechanisms. Together with renewed awareness of tumour-specific energy metabolism, research is pointed towards novel ways for targeting brain cancer. AREAS COVERED: This paper reviews recent knowledge on the possible tumourigenic mechanism of mutant isocitrate dehydrogenase, and provides a detailed overview of cancer-specific metabolic enzymes associated with glycolysis and intracellular pH regulation. It also discusses available drugs that may serve as a basis for novel drug development to target metabolic transformation in gliomas. EXPERT OPINION: Despite the fact that energy metabolism is a very basic cellular process, tumour specific alterations in key metabolic processes represent promising targets for glioma treatment. Novel therapies against gliomas, including those that target metabolic transformation, need to consider the genetic background of the individual tumours, to allow the correlation of treatment response with the underlying biological status, both in preclinical and clinical studies.

Disciplines :

Oncology

Author, co-author :

Stieber, Daniel; Centre de Recherche Public de la Santé (CRP-Santé), Oncology Department , NorLux Neuro-Oncology Laboratory, Luxembourg.

Abdul Rahim, Siti A

NICLOU, Simone P. ; Centre de Recherche Public de la Santé (CRP-Santé), Oncology Department, NorLux Neuro-Oncology Laboratory, Luxembourg, Luxembourg

External co-authors :

yes

Language :

English

Title :

Novel ways to target brain tumour metabolism.

Publication date :

October 2011

Journal title :

Expert Opinion on Therapeutic Targets

ISSN :

1472-8222

eISSN :

1744-7631

Publisher :

Taylor & Francis, United Kingdom

Volume :

Issue :

Pages :

1227-39

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBilu :

since 22 February 2024

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