- Author
-
I. Attaye
- Title
- The interaction between diet, ethnicity and the gut microbiota in metabolic health
- Supervisors
- Co-supervisors
-
H.J. Herrema
S.J. Pinto-Sietsma - Award date
- 3 March 2023
- Number of pages
- 233
- ISBN
- 9789492332486
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
This thesis aimed to study the interaction between diet, ethnicity and the gut microbiota in metabolic health. The thesis is divided into two parts. Part I of the thesis focused on summarizing the field's current knowledge regarding this interaction. Moreover, studies in this thesis identified important caveats in current literature that need to be addressed to gain more understanding of this complex interaction.
One of the main recommendations is that well-defined (analyses) methods must be registered before starting clinical trials to overcome bias in reporting data.
Part II of this thesis reports several (clinical) trials on the interaction between diet, ethnicity and the gut microbiota in metabolic health. One of the key findings is that host ethnicity impacts gut microbiota diversity, with South-Asian Surinamese having significantly lower gut microbiota diversity than Caucasian Dutch. This is of importance, as a low gut microbiota diversity has been well described to correspond to poor metabolic health. It is, therefore, possible that the higher cardio-metabolic risk that people of South-Asian Surinamese descent experience is partly mediated via the gut microbiota composition. Another important finding is that dietary protein modulation does not affect glycemic parameters but does alter serum (gut-derived) metabolite signatures in subjects with type 2 diabetes, showing that dietary modulation can indeed alter plasma metabolome through the gut microbiota. The results of this thesis add to the foundation of personalized medicine. - Persistent Identifier
- https://hdl.handle.net/11245.1/2f1508be-79ba-456a-aa22-f3f5b889ff91
- Downloads
- Supplementary materials
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