- Author
-
M.R. Smit
- Title
- Lung imaging in critically ill patients under mechanical ventilation
- Supervisors
-
M.J. Schultz
- Co-supervisors
- Award date
- 10 June 2022
- Number of pages
- 239
- ISBN
- 9789464582215
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
Patients with respiratory failure commonly require invasive mechanical ventilation at the intensive care unit. Lung imaging is crucial for monitoring of these patients and detection of pulmonary complications. The first part of the thesis describes empirical studies in lung ultrasound that were performed in invasively ventilated patients. We evaluated the difference in estimating lung aeration between a linear and sector array ultrasound probe and compared aeration estimation between lung ultrasound and computed tomography. The second part of the thesis focusses on lung imaging in patients with the acute respiratory distress syndrome (ARDS). The thesis describes the development and external validation of two lung ultrasound methods: (1) a lung ultrasound method for diagnosis of ARDS and (2) a lung ultrasound method that can classify patients with ARDS as having ‘focal’ or ‘non-focal’ lung morphology. Further, quantitative analysis of computed tomography scans at two levels of positive end-expiratory pressure was performed to assess lung re-aeration in patients with COVID-19 related ARDS. We thereafter assessed the relation between lung recruitability as measured with computed tomography with pulmonary biomarkers that are representative of multiple pathways in the development of ARDS.
- Persistent Identifier
- https://hdl.handle.net/11245.1/d8d3b174-b09b-4d62-bcb8-fe124dd05be7
- Downloads
-
Thesis (complete)
Front matter
Chapter 1: General introduction and outline of the thesis
Chapter 2: Assessment of the effect of recruitment maneuver on lung aeration through imaging analysis in invasively ventilated patients: A systematic review
Chapter 3: Ultrasound versus computed tomography assessment of focal lung aeration in invasively ventilated ICU patients
Chapter 4: Comparison of linear and sector array probe for handheld lung ultrasound in invasively ventilated ICU patients
Chapter 5: Lung ultrasound for diagnosis of acute respiratory distress syndrome: A prospective observational study
Chapter 6: Lung ultrasound assessment of focal and non-focal lung morphology in patients with acute respiratory distress syndrome
Chapter 7: Assessment of lung reaeration at 2 levels of positive end-expiratory pressure in patients with early and late COVID-19-related acute respiratory distress syndrome
Chapter 8: Relation between lung recruitability and biomarkers in COVID-19 related acute respiratory distress syndrome
Chapter 9: Summary
Chapter 10: General discussion
Chapter 11: Nederlandse samenvatting
Contributing authors and affiliations; Author contributions; List of publications; PhD portfolio; Acknowledgements; Curriculum vitae
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