Artículo
Biodegradation of Bi-Labeled Polymer-Coated Rare-Earth Nanoparticles in Adherent Cell Cultures
Autor/es | Liu, Ziyao
Escudero Belmonte, Alberto Carrillo Carrión, Carolina Chakraborty, Indranath Zhu, Dingcheng Gallego, Marta Parak, Wolfgang J. Feliu, Neus |
Departamento | Universidad de Sevilla. Departamento de Química Inorgánica |
Fecha de publicación | 2020-01-14 |
Fecha de depósito | 2024-02-02 |
Publicado en |
|
Resumen | The fate of polymer-coated Eu-and Bi-doped GdVO4 nanoparticles (NPs) of cubic shape upon cellular internalization was investigated. After having been endocytosed by cells, the cubic Eu-and Bi-doped GdVO4 NP cores were ... The fate of polymer-coated Eu-and Bi-doped GdVO4 nanoparticles (NPs) of cubic shape upon cellular internalization was investigated. After having been endocytosed by cells, the cubic Eu-and Bi-doped GdVO4 NP cores were partly dissolved and reshaped to rounded structures, which in control experiments could be ascribed to the acidic conditions present in endosomes/lysosomes. With progress of time, there was a significant reduction in the amount of internalized NPs per cell due to proliferation. This was of higher extent than NP exocytosis. Data of the study are compatible with the scenario that endosomal/lysosomal enzymes may partly digest the polymer shell around the NP cores, with enhanced exocytosis of the polymer fragments as compared to the NP cores. |
Agencias financiadoras | Deutsche Forschungsgemeinschaft (DFG) |
Identificador del proyecto | PA 794/25-1 |
Cita | Liu, Z., Escudero Belmonte, A., Carrillo Carrión, C., Chakraborty, I., Zhu, D., Gallego, M.,...,Feliu, N. (2020). Biodegradation of Bi-Labeled Polymer-Coated Rare-Earth Nanoparticles in Adherent Cell Cultures. Chemistry of Materials, 32 (1), 245-254. https://doi.org/10.1021/acs.chemmater.9b03673. |
Ficheros | Tamaño | Formato | Ver | Descripción |
---|---|---|---|---|
Biodegradation Of BI-Labeled_C.pdf | 1.467Mb | [PDF] | Ver/ | Versión aceptada |