Effects of Nicotine on Rat Alveolar Bone
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Date
2016
Journal Title
Journal ISSN
Volume Title
Publisher
Sci Printers & Publ Inc
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
OBJECTIVE: To investigate the effects of nicotine on periodontal membranes and alveolar bone using histopathological and immunohistochemical methods. STUDY DESIGN: Rats were divided into 2 groups: those systemically treated with nicotine sulfate (2 mg/kg subcutaneously, daily) for 28 days, and untreated controls. We analyzed the distribution of osteonectin and osteopontin immunohistochemically, with antibodies, in the maxillary region. RESULTS: In the treatment group, resorption of alveolar bone and vascular dilation, bleeding, periodontal membrane degeneration, hyalinization, and necrosis were seen in some areas. Negative osteoblastic activity was observed in immunohistochemical analyses of collagen fibers in the periodontal membrane. CONCLUSION: In short- and long-term nicotine consumption, soft tissue and alveolar bone are negatively affected during cell proliferation. This phenomenon may lead to a delay in treatment of implantation.
Description
Keywords
Alveolar Bone, Alveolar Bone Loss, Bone Sialoprotein 1, Collagen, Nicotine, Osteonectin, Osteopontin, Periodontal Bone Loss, Periodontitis, Smoking
Journal or Series
Analytical and Quantitative Cytopathology and Histopathology
WoS Q Value
Q4
Scopus Q Value
Q4
Volume
38
Issue
5
