Serotonergic modulation of behavioural choice in drosophila melanogaster

Download

index.pdf

Date

2017

Author

Yurt, Pınar

Metadata

Show full item record

Item Usage Stats

118
views

31
downloads

The monoamine modulator, serotonin (5-HT) has previously been shown to be involved in sleep, feeding, learning and memory, and anxiety in fruit flies. In this study, we used a behavioural paradigm where the flies choose to respond to either to a looming visual stimulus or an appetitive tastant. Using the GAL4-UAS binary system, selectively we activated or inactivated serotonergic neurons in the fly brain to understand the mechanisms of competitive inhibition between appetitive/feeding and aversive/escape behavioural systems. Unlike the results of previous experiments that involved acute manipulations of serotonergic neurons, our results failed to yield a reduction of feeding when we inactivated the same serotonergic neurons chronically using Gal4-R50H05>UASKir2.1. Likewise, we failed to observe overfeeding when we activated the same serotonergic neurons chronically using Gal4-R50H05>UAS-NaChBac. This discrepancy can be accounted for the difference between acute and chronic manipulations. However, because the visual responsiveness increased upon chronic activation of the serotonergic neurons, we suggest that the serotonergic neurons of interest might be modulating sensory integration areas rather than hunger per se.

Subject Keywords

Serotonin., Drosophila.

URI

http://etd.lib.metu.edu.tr/upload/12621640/index.pdf
https://hdl.handle.net/11511/26923

Collections

Graduate School of Informatics, Thesis

Suggestions

OpenMETU
Core

Neuroprotective Efficacy of the Peroxisome Proliferator-Activated Receptor-gamma Ligand in Chronic Cerebral Hypoperfusion SAYAN ÖZAÇMAK, HALE; SAYAN, Hale; BARUT, FİGEN; Jakubowska-Dogru, Ewa (Bentham Science Publishers Ltd., 2011-08-01) Chronic cerebral hypoperfusion can cause learning and memory impairment and neuronal damage resembling the effects observed in vascular dementia. PPAR-gamma agonists were shown to modulate inflammatory response and neuronal death following cerebral ischemia. The present study was designed to evaluate possible neuroprotective effects of rosiglitazone, a PPAR-gamma agonist, in rat model of chronic cerebral hypoperfusion. Cerebral hypoperfusion was induced by permanent bilateral occlusion of the common carotid...
A Plasmonic method for the determination of serotonin Avcı, Begüm; Volkan, Mürvet; Department of Chemistry (2019) Serotonin is an important neurotransmitter for regulating many cognitive and behavioral functions. Its abnormal levels have been related with various diseases hence the determination of the serotonin is very important. Sialic acid is mostly found in acidic glycan chains, glycolipids and glycoproteins and it is known to have a specific affinity for serotonin. In this study, determination of serotonin by using plasmonic property of gold nanoparticles was aimed. After synthesizing gold nanoparticles through si...
The effects of repeated antibiotic administration to juvenile BALB/c mice on the microbiota status and animal behavior at the adult age Ceylani, Taha; Jakubowska-Dogru, Ewa; Gurbanov, Rafig; Teker, Hikmet Taner; Gözen, Ayşe Gül (2018-06-01) Recent studies carried on germ -free (GF) animal models suggest that the gut microbiota (GM) may play a role in the regulation of anxiety, mood, and cognitive abilities such as memory and learning processes. Consistently, any treatment disturbing the gut microbiota, including the overuse of antibiotics, may influence the brain functions and impact behavior. In the present study, to address this issue, two wide-spectrum antibiotics (ampicillin and cefoperazone, 1 g/l) were repeatedly applied throughout a 6-w...
SRC family kinase inhibitors antagonize the toxicity of multiple serotypes of botulinum neurotoxin in human embryonic stem cell-derived motor neurons. Kiriş, Erkan; Nuss, JE; Wanner, LM; Peyser, BD; Du, HT; Gomba, GY; Kota, KP; Panchal, RG; Gussio, R; Kane, CD; Tessarollo, L; Bavari, S (2015-05-01) Botulinum neurotoxins (BoNTs), the causative agents of botulism, are potent inhibitors of neurotransmitter release from motor neurons. There are currently no drugs to treat BoNT intoxication after the onset of the disease symptoms. In this study, we explored how modulation of key host pathways affects the process of BoNT intoxication in human motor neurons, focusing on Src family kinase (SFK) signaling. Motor neurons derived from human embryonic stem (hES) cells were treated with a panel of SFK inhibitors a...
Ginseng and Ginkgo Biloba Effects on Cognition as Modulated by Cardiovascular Reactivity: A Randomised Trial Teik, Derek Ong Lai; Lee, Xiao Shiang; Lim, Chu Jian; Low, Chia Mei; Muslima, Mariyam; Aquili, Luca (Public Library of Science (PLoS), 2016-03-03) Background

Citation Formats

P. Yurt, “Serotonergic modulation of behavioural choice in drosophila melanogaster,” M.S. - Master of Science, Middle East Technical University, 2017.