Folic acid functionalized PEG coated magnetic nanoparticles for targeting anti-cancer drug delivery: Preparation, characterization and cytotoxicity on Doxorubicin, Zoledronic acid and Paclitaxel resistant MCF-7 breast cancer cell lines

Date

2018-01-01

Author

Keskin, Tugba
Yalcin, Serap
Gündüz, Ufuk

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In this study, MNPs were synthesized, coated with biocompatible polyethylene glycol (PEG) and conjugated with folic acid. Crystal and chemical structures, shape, size and magnetic properties of synthesized nanoparticles were characterized. Agglomeration tendency of naked nanoparticles were prevented by oleic acid addition during the synthesis. All synthesized MNPs have been found to exhibit superparamagnetic behavior at 23 degrees C and 37 degrees C. Cytotoxic effects of MNPs were investigated on Doxorubicin, Zoledronic acid and Paclitaxel resistant MCF-7 breast cancer cell lines. The synthesized nanoparticles have been found to be suitable for drug targeting in terms of size, shape, magnetic and cytotoxic properties.

Subject Keywords

Folic acid, Polyethylene glycol (PEG), Magnetic nanoparticle, Drug delivery, MCF-7, Drug targeting

URI

https://hdl.handle.net/11511/32135

Journal

INORGANIC AND NANO-METAL CHEMISTRY

DOI

https://doi.org/10.1080/24701556.2018.1453840

Collections

Graduate School of Natural and Applied Sciences, Article

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Citation Formats

T. Keskin, S. Yalcin, and U. Gündüz, “Folic acid functionalized PEG coated magnetic nanoparticles for targeting anti-cancer drug delivery: Preparation, characterization and cytotoxicity on Doxorubicin, Zoledronic acid and Paclitaxel resistant MCF-7 breast cancer cell lines,” INORGANIC AND NANO-METAL CHEMISTRY, pp. 150–159, 2018, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/32135.