Small molecule detection by lateral flow strips via aptamer-gated silica nanoprobes

Date

2016-01-01

Author

Ozalp, V. Cengiz
Cam, Dilek
Hernandez, Frank J.
Hernandez, Luiza I.
Schafer, Thomas
Öktem, Hüseyin Avni

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A fast, sensitive and ratiometric biosensor strategy for small molecule detection was developed through nanopore actuation. The new platform engineers together, a highly selective molecular recognition element, aptamers, and a novel signal amplification mechanism, gated nanopores. As a proof of concept, aptamer gated silica nanoparticles have been successfully used as a sensing platform for the detection of ATP concentrations at a wide linear range from 100 mu M up to 2 mM.

Subject Keywords

Nanoparticles, Adenosine, Strategy, Tools, Assay

URI

https://hdl.handle.net/11511/42355

Journal

ANALYST

DOI

https://doi.org/10.1039/c6an00273k

Collections

Department of Biology, Article

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Citation Formats

V. C. Ozalp, D. Cam, F. J. Hernandez, L. I. Hernandez, T. Schafer, and H. A. Öktem, “Small molecule detection by lateral flow strips via aptamer-gated silica nanoprobes,” ANALYST, pp. 2595–2599, 2016, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/42355.