Experimental investigation of hemodynamics in abdominal aortic aneurysm

2022-9
Fathipour, Amirhossein
Abdominal aortic aneurysm (AAA), the enduring enlargement of the aorta, is a serious clinical condition with a very high mortality rate when it ruptures. Even though the precise causes of the dilation and rupture mechanisms of the aorta are still unknown, flow-related structures inside the AAA, including vortex formations and wall shear stresses, are associated with these mechanisms. The present study aims to characterize the flow patterns and their evolutions in two aneurysm models, simplified elliptic geometry and patient-specific geometry, under physiological flows. For the characterization, an optical velocity measurement technique, 2-D planar Particle Image Velocimetry (PIV), was employed in an In-vitro physiological flow set-up. For the simple model, the center plane was used for the measurement plane, whereas for the patient-specific model, due to its complex geometry, the flow fields at three different planes were quantified. The phase-averaged velocity, vorticity, and swirling strength ( ci) contours were constructed along with the streamline patterns. The results indicate that a vortex ring and the formation of two additional vortical structures are apparent in the simplified aneurysm model during the physiological cycle. In the patient-specific aneurysm model, the flow is highly 3-D, and relatively weak vortex formations are evident without a clear indication of a vortex ring. Different recirculation regions at different instants of the physiological vi cycle are also apparent. Further studies are needed for a complete understanding of flow structure in the patient-specific aneurysm model.

Suggestions

Characterization of vortex ring in abdominal aortic aneurysm phantom using particle image velocimetry
Gökçek, Kerem Tuğ; Yavuz, Mehmet Metin; Department of Mechanical Engineering (2021-9)
Abdominal aortic aneurysm (AAA) is the permanent enlargement of the abdominal artery that may even rupture at the end, and it is a critical medical situation with a high mortality rate. Although there are some approaches to model its enlargement and rupture, a complete understanding is far from over. A vortex ring is generated during physiological flow pattern, and its evolution should be analyzed in detail to understand its effect on the flow field. The aim of this study is to investigate and characterize ...
Growth model for abdominal aortic aneurysms using longitudinal CT images
Akkoyun, Emrah; Acar, Aybar Can; Department of Health Informatics (2020)
An Abdominal Aortic Aneurysm (AAA) is diagnosed by an enlargement of the abdominal aorta. The rupture of an AAA, associated with high mortality, is eventually observed if no surgical intervention is performed. Aneurysm repair prior to rupture is thus vital. The decision to intervene is made primarily based on the AAA size measured by a maximum diameter or its growth rate. However, 10 – 24% of aneurysms below the intervention threshold experience rupture in some series. There are many complex interactions in...
Biomechanical Investigation of Disturbed Hemodynamics-Induced Tissue Degeneration in Abdominal Aortic Aneurysms Using Computational and Experimental Techniques
Salman, Huseyin Enes; Ramazanlı, Burcu; Yavuz, Mehmet Metin; Yalcin, Huseyin Cagatay (2019-05-31)
Abdominal aortic aneurysm (AAA) is the dilatation of the aorta beyond 50% of the normal vessel diameter. It is reported that 4-8% of men and 0.5-1% of women above 50 years of age bear an AAA and it accounts for similar to 15,000 deaths per year in the United States alone. If left untreated, AAA might gradually expand until rupture; the most catastrophic complication of the aneurysmal disease that is accompanied by a striking overall mortality of 80%. The precise mechanisms leading to AAA rupture remains unc...
Characterization of wall shear stress in abdominal aortic aneurysm phantom using particle image velocimetry
Türk, Semih; Yavuz, Mehmet Metin; Department of Mechanical Engineering (2021-9)
Abdominal Aortic Aneurysm (AAA) is defined as the enlargement of the largest artery in the abdominal cavity, the abdominal aorta. The vascular rupture begins to pose a risk after a certain enlargement, and the rupture is described as one of the most critical emergencies in medicine. The disease is labeled as the 14th disease with the highest mortality rate. Thus, predicting the progression of the disease is vitally important. Hence, researchers are trying to identify and standardize all biological and mecha...
Investigation of on skin surface response due to acoustic radiation from stenosed blood vessels
Salman, Huseyin E.; Yazıcıoğlu, Yiğit (2015-11-02)
Arterial stenosis is a form of cardiovascular disease which leads to highest rate of fatalities worldwide. When stenosis is present in coronary arteries, it leads to heart attack and often sudden death. Arterial disease is usually not confined to critical organs such as the heart and the brain but observed throughout the peripheral cardiovascular system. When an artery has a diameter reduction, acoustic radiation originating from this constriction propagates through soft tissues and reaches to skin surface....
Citation Formats
A. Fathipour, “Experimental investigation of hemodynamics in abdominal aortic aneurysm,” M.S. - Master of Science, Middle East Technical University, 2022.