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The prototypic mineralocorticoid receptor agonist aldosterone influences neurogenesis in the dentate gyrus of the adrenalectomized rat

MPS-Authors

Fischer,  AK
Max Planck Institute of Psychiatry, Max Planck Society;

von Rosenstiel,  P
Max Planck Institute of Psychiatry, Max Planck Society;

Fuchs,  E
Max Planck Institute of Psychiatry, Max Planck Society;

Goula,  D
Max Planck Institute of Psychiatry, Max Planck Society;

Almeida,  OFX
Max Planck Institute of Psychiatry, Max Planck Society;

Czeh,  B
Max Planck Institute of Psychiatry, Max Planck Society;

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Citation

Fischer, A., von Rosenstiel, P., Fuchs, E., Goula, D., Almeida, O., & Czeh, B. (2002). The prototypic mineralocorticoid receptor agonist aldosterone influences neurogenesis in the dentate gyrus of the adrenalectomized rat. Brain Research, 947(2), 290-293.


Cite as: https://hdl.handle.net/11858/00-001M-0000-000E-A195-0
Abstract
Glucocorticoid receptor activation inhibits granule cell proliferation in the hippocampus. but little is known about the role of mineralocorticoid receptors in this process. Here we administered aldosterone to adrenalectomized (ADX) rats, and monitored neurogenesis by BrdU immunohistochemistry. ADX significantly increased the number of BrdU-positive cells and aldosterone replacement further augmented BrdU-positivity. Our results indicate that aldosterone, most probably acting through mineralocorticoid receptors, may positively influence the proliferation and survival of newly-generated granule cells. (C) 2002 Elsevier Science B.V. All rights reserved