Direct activation of the ion channel TRPA1 by Ca2+.

Zurborg, Sandra; Yurgionas, Brian; Caspani, Ombretta; Heppenstall, Paul A.

doi:10.1038/nn1843

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Direct activation of the ion channel TRPA1 by Ca2+.

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Citation

Zurborg, S., Yurgionas, B., Caspani, O., & Heppenstall, P. A. (2007). Direct activation of the ion channel TRPA1 by Ca2+. Nature Neuroscience, 10(3), 277-279. doi:10.1038/nn1843.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0012-09B4-7

Abstract

TRPA1 is an ion channel expressed by nociceptors and activated by irritant compounds such as mustard oil. The endogenous function of TRPA1 has remained unclear, a fact highlighted by ongoing debate over its potential role as a sensor of noxious cold. Here we show that intracellular Ca(2+) activates human TRPA1 via an EF-hand domain and that cold sensitivity occurs indirectly (and nonphysiologically) through increased [Ca(2+)](i) during cooling in heterologous systems.