Design, synthesis and characterization of new smart MR contrast agents 
sensitive to pH

Mishra, AK; Pfeuffer, J; Mishra, A; Logothetis, NK

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Design, synthesis and characterization of new smart MR contrast agents sensitive to pH

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Mishra, AK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Pfeuffer, J
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Mishra, A
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Logothetis, NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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引用

Mishra, A., Pfeuffer, J., Mishra, A., & Logothetis, N. (2005). Design, synthesis and characterization of new smart MR contrast agents sensitive to pH. Poster presented at 13th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM 2005), Miami Beach, FL, USA.

引用: https://hdl.handle.net/11858/00-001M-0000-0013-D5A5-A

要旨

New gadolinium-based MR contrast agents Gd-DO3A-EP (-phosphono-ethyl) and Gd-DO3A-EPE (-diethyl-phosphono-ethyl) were designed and synthesized to trace physiological changes of pH and calcium concentration in the extracellular space of brain. Phosphonate derivatives are known to have very high affinity towards calcium (MDP, methylene-diphosphonate) and can function as reporters of pH and calcium ions. Ethyl-phosphonate is appended
covalently on the macrocycle without any amide linkage and binds reversibly as a function of pH/calcium concentration acting as reporter of cellular activity and neurotransmission. Here we demonstrate in-vitro MR relaxation changes induced by changes in pH revealing 50 changes in relaxivity r1.