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Associations of fearful spells and panic attacks with incident anxiety, depressive, and substance use disorders: A 10-year prospectivelongitudinal community study of adolescents and young adults

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Wittchen,  Hans-Ulrich
Max Planck Institute of Psychiatry, Max Planck Society;
Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden;

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Lieb,  Roselind
Max Planck Institute of Psychiatry, Max Planck Society;

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Citation

Asselmann, E., Wittchen, H.-U., Lieb, R., Hoefler, M., & Beesdo-Baum, K. (2014). Associations of fearful spells and panic attacks with incident anxiety, depressive, and substance use disorders: A 10-year prospectivelongitudinal community study of adolescents and young adults. JOURNAL OF PSYCHIATRIC RESEARCH, 55, 8-14. doi:10.1016/j.jpsychires.2014.04.001.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0024-7869-9
Abstract
Objective: The concept of fearful spells (FS) denotes distressing spells of anxiety that might or might not qualify for criteria of panic attacks (PA). Few studies examined prospective-longitudinal associations of FS not meeting criteria for PA with the subsequent onset of mental disorders to clarify the role of FS as risk markers of psychopathology. Method: A representative community sample of adolescents and young adults (N = 3021, age 14-24 at baseline) was prospectively followed up in up to 3 assessment waves over up to 10 years. FS, PA, anxiety, depressive, and substance use disorders were assessed using the DSM-IV/M-CIDI. Odds Ratios (OR) from logistic regressions were used to examine the predictive value of FS-only (no PA) and PA at baseline for incident disorders at follow-up. Results: In logistic regressions adjusted for sex and age, FS-only predicted the onset of any subsequent disorder, any anxiety disorder, panic disorder, agoraphobia, GAD, social phobia, any depressive disorder, major depression, and dysthymia (ORs 1.54-4.36); PA predicted the onset of any anxiety disorder, panic disorder, GAD, social phobia, any depressive disorder, major depression, dysthymia, any substance use disorder, alcohol abuse/dependence, and nicotine dependence (ORs 2.08-8.75; reference group: No FS-only and no PA). Associations with psychopathology were slightly smaller for FS-only than for PA, however, differences in associations (PA compared to FS-only) only reached significance for any anxiety disorder (OR = 3.26) and alcohol abuse/dependence (OR = 2.26). Conclusions: Findings suggest that compared to PA, FS-only have similar predictive properties regarding subsequent psychopathology and might be useful for an early identification of high-risk individuals. (C) 2014 Elsevier Ltd. All rights reserved.